Professor auxiliar
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Docentes Universitário
Unidade ID
Algarve Biomedical Center Research Institute
Unidade ID externa
Instituto de Investigação e Inovação em Saúde (i3S)
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Fátima Macedo (https://www.webofscience.com/wos/author/record/L-4623-2013) is a Assistant Professor at Faculty of Medicine and Biomedical Sciences, University of Algarve. In addition she is a researcher at ABC-Ri. Fátima Macedo received a PhD in Biomedical Sciences in 2006, a master's degree in Immunology in 1999 and a BSc degree in Biology in 1996, all from University of Porto, Portugal. During her PhD and Masters degree she was a visiting student at Harvard University, Boston and Loyola University in Chicago, USA respectively. Her doctorate focused on T-lymphocyte biology in the context of iron overload. In this context, she addressed different diseases of iron overload with a genetic cause including Hemochromatosis. After her PhD, she developed an interest in a population of T lymphocytes that recognize lipids (CD1-restricted T lymphocytes). Fátima has been working on lipid specific T lymphocytes in Lysosomal Storage Diseases, mainly sphingolipidoses. Her research team focus is understanding the role of sphingolipids for the modulation of CD1 restricted T lymphocytes, including Natural Killer T cells, and understanding the role of this modulation in different pathological conditions including sphingolipidoses like Acid Sphingomyelinase Deficiency, Gaucher and Fabry diseases. Fatima Macedo established a line of research that joins the CD1 and LSD fields that has been recognised nationally and internationally, as illustrated by establishing relevant collaborations with international leaders in the field of CD1-restricted T cells and with clinicians of National and International Reference Centers for Hereditary Metabolic Diseases, illustrated by joint publications and successfully attracting national and international funding. Fatima successful graduated 23 MSc and 3 PhD students, and supervised 2 postdoc researchers. She published 31 papers including publications on the Molecular Genetic and Metabolism Journal, the official journal of the Society for Inherited Metabolic Disorders, as well as publications on Nature Immunology and The European Journal of Immunology. Fatima Macedo has received invitations for plenary talks and her work has received several awards including The Gaucher Generation Award and awards from the Portuguese Society of Metabolic Diseases. Along with her scientific carrear Fátima Macedo has 20 years experience in teaching in higher education institutions including 17 year of experience in the teaching/learning method of Problem Based Learning (PBL).
Atividades
Atividades
2025/09/01 - Presente. Orientação. Characterization of kidney iNKT cells of alpha galactosidase knock-out mice. Orientador.
2025/09/01 - Presente. Orientação. Characterization of iNKT cells in the intestine of alpha-galactosidase knockout mice. Orientador.
2025/01/02 - Presente. Curso / Disciplina lecionado. Since January 2025 Assistant Professor at the Medical and Biomedical Sciences Faculty of Algarve University. Universidade do Algarve.
2025/07/15. Júri de grau académico. Fabry disease: from iPS cells to genomic editing. Arguente principal. Ana Joana Borges Duarte (Doutoramento). Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar.
2025/05/27. Júri de grau académico. Genetic. Lysosomal Storage Diseases.. Vogal. Juliana lnês Pinto dos Santos (Doutoramento). Universidade do Porto Faculdade de Ciências.
2025/04/29 - 2025/04/29. Organização de evento. Organization of the celebration of International Immunology Day in Faro, Algarve, Portugal. International Immunology Day is an event celebrated internationally on April 29th to bring Immunology closer to the general public. In Faro Fátima Macedo promoted this celebration at the FNAC with a talk given by Dr. Pedro Morais Silva. (2025). Universidade do Algarve.
2025/04/03. Apresentação oral de trabalho. Genetic Immunodeficiencies.. 6th edition of “Genetically speaking with...”. Portuguese Society of Genetic (Online, Portugal).
2023/01/27. Júri de grau académico. Studies on the diagnose and therapy of breast cancer
. Vogal. Fátima Liliana Ribeiro Vieira Monteiro (Doutoramento). Universidade de Aveiro.
. Vogal. Fátima Liliana Ribeiro Vieira Monteiro (Doutoramento). Universidade de Aveiro.
2025/02/25. Apresentação oral de trabalho. Techniques for analyzing the diversity of cells in the immune system.. Open Days of the University of Algarve. University of Algarve (Faro, Portugal).
2023/09/01 - 2024/12/12. Orientação. Effect of Enzyme Replacement Therapy on Invariant Natural Killer T Cell Function in Patients With Acid Sphingomyelinase Deficiency.Biochemistry (Mestrado). Orientador.
2023/09/01 - 2024/12/05. Orientação. Characterization of a new population of iNKT cells, using the a-galactosidase A-deficient mouse as a model.Biochemistry (Mestrado). Orientador.
2024/09 - 2024/10. Comissão de avaliação. Review a research proposal that was submitted to the National Science Centre, Poland (http://www.ncn.gov.pl). Funding scheme: PRELUDIUM 23; Panel Cellular and Developmental Biology.. National Science Centre. National Science Centre.
2007 - 2024/09/30. Curso / Disciplina lecionado. Invited assistant professor at the Biomedical Science degree of Aveiro University. Universidade de Aveiro.
2024/09/18 - 2024/09/20. Arbitragem científica em conferência. 4th International Conference on Natural Products in Human Health . Aveiro University.
2024/09/18 - 2024/09/20. Organização de evento. 4th International Conference on Natural Products in Human Health (2024). Universidade de Aveiro.
2022/09/01 - 2023/10/31. Orientação. Phenotypic and functional characterization of iNKT cells in Fabry disease patients.Mestrado em Investigação Biomédica (Mestrado). Orientador.
2023/05/04 - 2023/05/05. Organização de evento. International Symposium on Integrative Medicine & Health-Drug discovery for human heath pandemic preparedness (2023). Universidade de Aveiro.
2023/03/29 - 2023/03/31. Arbitragem científica em conferência. 48 Anual Meeting Portuguese Society for Immunology. Portuguese Society of Immunology.
2023/03/16 - 2023/03/18. Arbitragem científica em conferência. XIII Jornadas Nacionais de Ciências Biomédicas. Aveiro University.
Revisão ad hoc de artigos em revista. Blood.
Revisão ad hoc de artigos em revista. Frontiers in Cellular and Infection Microbiology.
Revisão ad hoc de artigos em revista. Nano and Medical Materials.
Revisão ad hoc de artigos em revista. Frontiers in Cell and Developmental Biology.
Revisão ad hoc de artigos em revista. Biomedicines.
Revisão ad hoc de artigos em revista. PLOS ONE .
Revisão ad hoc de artigos em revista. Frontiers in Immunology.
2022/11/29. Apresentação oral de trabalho. Flow cytometry approach to study Lysosomal Storage Disease Inflammation. Approaches for inflammation research: limitations and troubleshooting. Aveiro University (Online, Portugal).
2021/09/01 - 2022/11/25. Orientação. Buffy coat verus blood collection tube monocytes: a functional characterization.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2022/11/11. Apresentação oral de trabalho. Does the level of substrate impact immunity status?. Global Symposium on Lysosomal Storage Disorders (GSLSD) 2022.
2022/07/22 - 2022/07/22. Organização de evento. 2nd Workshop Sphingolipids in Health and Disease (2022). Universidade de Aveiro.
2022 - 2022. Comissão de avaliação. Evaluator of research projects submited to "Innovate Competition", iMed Conference 14.0-Lisbon 2022. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa..
Revisão ad hoc de artigos em revista. The FEBS Journal.
Revisão ad hoc de artigos em revista. Orphanet Journal of Rare Diseases.
Revisão ad hoc de artigos em revista. International Journal of Molecular Sciences.
2021/12/10. Júri de grau académico. Effect of diferente buffy coat processing on monocyte function. Orientador. Inês Martins Mondragão Rodrigues (Mestrado). Universidade de Aveiro.
2020/09/15 - 2021/12/10. Orientação. Effect of diferente buffy coat processing on monocyte function.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2021/12/09. Júri de grau académico. Human iNKT cells as key modulators of macrophage survival and phenotype. Orientador. Mariana Santos Cruz (Mestrado). Universidade de Aveiro.
2020/09/15 - 2021/12/09. Orientação. Human iNKT cells as key modulators of macrophage survival and phenotype.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2021/07 - 2021/08. Comissão de avaliação. Evaluation of Final Scientific Reports of Research and Development Units 2019. Fundação para a Ciência e a Tecnologia.
2021/05/19. Apresentação oral de trabalho. Basic principles of immunological memory and vaccination. . Round table on COVID-19 Pandemic and Vaccination: opportunities and challenges . Aveiro University (Online, Portugal).
2021/04/29. Apresentação oral de trabalho. Immunological response: with and without memory. Pint of Science Aveiro. Pint of Science Aveiro (Online, Portugal).
2021 - 2021. Comissão de avaliação. Evaluator of research projects submited to “Innovate Competition”, iMed Conference 13.0-Lisbon 2021. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa..
2019 - 2020/12/09. Orientação. iNKT cells and MAIT cells in Gaucher disease.Investigação Biomédica (Mestrado). Orientador.
2016/01/01 - 2020/12/05. Orientação. The relevance of lipid accumulation in lysosomal storage diseases in immune cells function.Doutoramento em Bioquímica. Orientador.
2020 - 2020. Comissão de avaliação. Evaluator of research projects submited to “Innovate Competition”, iMed Conference 12.0-Lisbon 2020. Student Association of Nova Medical School/ Medical Science Faculty, Universidade Nova de Lisboa..
Revisão ad hoc de artigos em revista. Cells.
Revisão ad hoc de artigos em revista. Clinical Immunology.
2019/09/19. Júri de grau académico. The Macrophage-iNKT cell axis: macrophage survival and activation are modulated upon invariante NKT cell interation. Orientador. José Pedro Loureiro (Mestrado). Hospitais da Universidade de Coimbra.
2019 - 2019. Comissão de avaliação. Evaluation of Scientific projects submitted to the PEPITA "Program to stimulate translational research projects" at Coimbra University.
2018 - 2019. Orientação. The Macrophage-iNKT cell axis: macrophage survival and activation are modulated upon invariant NKT cell interation.Mestrado em Investigação Biomédica (Mestrado). Orientador.
2018/12/21. Júri de grau académico. Characterization of CD5 and CD6 expression by invariant Natural Killer T cells. Orientador. Ana Margarida Cunha (Mestrado). Universidade de Aveiro.
2017/09/01 - 2018/12/18. Orientação. Characterisation of CD5 and CD6 expression by invariant Natural Killer Cells.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2018/12/13. Júri de grau académico. Characterization of peripheral blood lymphocytes in Juvenile Idiopathic Arthritis. Vogal. Cláudia Marques (Mestrado). Universidade de Aveiro.
2017/09/01 - 2018/12/13. Orientação. Characterization of peripheral blood lymphocytes in Juvenile Idiopathic Arthritis.Mestrado em Biologia Molecular e Celular (Mestrado). Coorientador.
2017/02/01 - 2018/11/30. Orientação. Post Doc supervision. Post Doc research title: Lipid antigen presentation in Gaucher disease. Orientador.
2018/05/29. Júri de grau académico. Refining thymic epithelial cell differentiation: from progenitor cell isolation to the identification of discrete mature lineages. Vogal. Helena Catarina Teixeira Meireles (Doutoramento). Universidade do Porto.
2018/05/05. Apresentação oral de trabalho. Lysosomal Storage Diseases – Implications of Glycosphingolipid storage for NKT cells. Recent Advances in Rare Diseases (RARD).
2018/02/18. Apresentação oral de trabalho. Specificity versus promiscuity in lipid recognition by the Immune System. 7th workshop in Lipidomics.
2016/01/25. Júri de grau académico. Impact of limp-2 deficiency on lysosome composition and function. Vogal. Paulo Jorge Miranda da Silva Gaspar (Doutoramento). Universidade do Porto.
2018 - 2018. Comissão de avaliação. Evaluate research projects PEPITA: "program to stimulate translation research projects" at Coimbra University.
2018 - 2018. Comissão de avaliação. Evaluate a research project for the Medical Research Council MRC.
2017/11/05. Apresentação oral de trabalho. Immune dysregulation in Fabry disease: Insights from the mouse models. Genetic, Rare & Immune Disorders Symposium (GRIDS).
2017/10/27. Júri de grau académico. Impact of H-ferritin deficiency on macrophage viability and iron status. Arguente. Gonçalo Augusto Taborda da Costa Laranja Mesquita (Mestrado). Universidade da Beira Interior.
2017/09/22. Júri de grau académico. Leishmania infantum extracellular material and human invariant natural killer T cells: a functional study. Vogal. Renata Cardoso Belo da Costa (Mestrado). Universidade do Porto.
2017/07/03. Apresentação oral de trabalho. “Implications of Glycosphingolipid storage in T cell Immunity. MASSTRPLAN-Summer School”, .
2012 - 2017. Orientação. The peroxisomal matrix protein import machinery – a PEX5 – centered perspective.Doutoramento em Ciências Biomédicas. Coorientador.
2016/06/01 - 2016/12/31. Orientação. Post Doc supervision of Catia Sofia Pereira. Project title: Lipid antigen presentation in Lysosomal Storage Diseases . Orientador.
2016/12/13. Júri de grau académico. The impact of Chronic Obstructive Pulmonary Disease on iNKT lymphocytes. Orientador. Tânia Marante (Mestrado). Universidade de Aveiro.
2016/10/24. Apresentação oral de trabalho. NKT cells and CD1. Advanced course in Molecular Immunology”.
2016/10/17. Júri de grau académico. Heme and iron shape macrophage plasticity: a role in hemolytic disorders and cancer. Vogal. Milene Soraia Costa da Silva (Doutoramento). Universidade do Porto.
2016/05/03. Júri de grau académico. Lipid-specific T cells in Fabry disease, Gaucher disease and GM2 gangliosidosis. Orientador. Cátia Sofia Oliveira Pereira (Doutoramento). Universidade do Porto.
2016/04/29. Apresentação oral de trabalho. The cross talk between innate and adaptive immunity. International Immunology Day.
2016/03/17. Apresentação oral de trabalho. Lysosomal Storage Diseases - Implications of Glycosphingolipid storage in Immunity. 12th International Symposium of the Portuguese Society of Metabolic Diseases.
2016 - 2016. Comissão de avaliação. Evaluate research projects submitted to the “The Israel Science Foundation (ISF)”.
2015 - 2016. Orientação. Dissecting the molecular basis for the arrest of Plasmodium sporozoites in the liver sinusoids.Mestrado em Microbiologia (Mestrado). Coorientador.
2015 - 2016. Orientação. The impact of Chronic Obstructive Pulmonary Disease on iNKT cells.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2011 - 2016. Orientação. Lipid specific T cells in Fabry, Tay-Sachs and Gaucher diseases.Doutoramento em Ciências Biomédicas (Doutoramento). Orientador.
2015/06/06 - 2015/06/06. Entrevista / Programa (rádio / tv). Interview at Antena 1 radio station, concerning my Award with the Gaucher Generation Award.
2015/06. Júri de grau académico. Studying the role of Lipocalin-2 in the pathophysiology of multiple sclerosis – looking beyond the brain. Arguente. Sofia Pereira das Neves (Mestrado). Universidade do Minho.
2015/05/06. Apresentação oral de trabalho. Sphingolipids as Immune System Modulators. 4th Workshop in Lipidomics.
2015/04/03. Júri de grau académico. B lymphocytes in patients with type VI Mucopolysaccharidosis. Orientador. Cátia Daniela Isaías Pereira (Mestrado). Universidade de Aveiro.
2014 - 2015. Orientação. Regulation of iron metabolismo in diferente bacterial infections.Mestrado em Biomedicina Molecular (Mestrado). Coorientador.
2014 - 2015. Orientação. B lymphocytes in MPS VI patients.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2014/12/03. Júri de grau académico. A multiparametric assessment of thymic activity on HIV infected individuals on anti-retroviral therapy. Arguente. Ana Patrícia Pimenta Martins Ribeiro (Mestrado). Universidade do Minho.
2014/11/03. Júri de grau académico. Functional characterization of immune cells presente in the adipose tissue of mice infected with Neospora caninum. Arguente. João Pedro Silva Moreira (Mestrado). Universidade do Porto.
2014/09/18 - 2014/09/18. Organização de evento. Organising symposium: "Sphingolipids in Health and Disease" (2014).
2014/05/30. Apresentação oral de trabalho. Immune System Dysfunction in Gaucher Disease. Gaucher disease: new perspectives.
2014/04/02. Apresentação oral de trabalho. Lipids and lymphocyte immune response. Science and Technology Week at the University of Évora.
2014/03/06. Júri de grau académico. INKT Cells in Metabolic Diseases Hemochromatosis and Gaucher Disease. Orientador. Inês Pinheiro (Mestrado). Universidade de Aveiro.
2013 - 2014. Orientação. INKT Cells in Metabolic Diseases Hemochromatosis and Gaucher Disease.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2013 - 2014. Orientação. HIF-1alpha relevance in necrosis of Mycobacterium avium-induced granulomas.Mestrado em Biologia Molecular e Celular (Mestrado). Coorientador.
2013/11/22. Apresentação oral de trabalho. Immune system in Gaucher disease. 5th Gaucher Leadership Forum (GLF).
2013/09/01. Júri de grau académico. Study of the effect of genetic suppression of the Nrf2 signaling pathway in an animal model of spontaneous iron overload (Hfe knock-out). Arguente. Carolina Pontes Geraz Caldas (Mestrado). Universidade de Aveiro.
2013/05/05. Júri de grau académico. Mhc in Sea bass: molecular insights to class I antigen presentation. Vogal. Rute Daniela Pinheiro da Silva Pinto (Doutoramento). Universidade do Porto.
2013/05/03. Júri de grau académico. Could the immunesenescence among aged individuals be related with their distinct cognitive performances?. Arguente. Cláudia Sofia Serre Miranda (Mestrado). Universidade do Minho.
2013/04/04. Júri de grau académico. Towards the molecular understanding of BACE and Abeta physiological role in thymus development and function. Arguente. Ana Cláudia da Rocha Ribeiro (Mestrado). Universidade do Minho.
2013/03/14. Apresentação oral de trabalho. The impact of sphingolipid storage in the immune system. 4th National Days of Biomedical Sciences.
2013/03/05. Júri de grau académico. INKT lymphocytes in patients with type II Mucopolysaccharidosis. Orientador. Nuno Duarte Ribeiro Lopes (Mestrado). Universidade de Aveiro.
2012 - 2013. Orientação. Characterization of the NKT cell populations in MPS II patients. Orientador.
2004 - 2013. Curso / Disciplina lecionado. Teaching undergraduate students at the Health School Piaget Institute. Instituto Piaget.
2012/09/21. Apresentação oral de trabalho. Immune dysregulation in Gaucher disease. 4th Gaucher Leadership Forum (GLF).
2012/01/03. Júri de grau académico. Lipid-specific T cells in patients with Mucopolysaccharidosis VI
. Orientador. Maria da Luz Galante Maia (Mestrado). Universidade de Aveiro.
. Orientador. Maria da Luz Galante Maia (Mestrado). Universidade de Aveiro.
2012/03/29. Júri de grau académico. Immune System Involvement in Gaucher disease: analysis of HLA and KIR gene variants. Arguente. Filippo Pinto E. Vairo (Mestrado). Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Brasil.
2011 - 2012. Orientação. Lipid specific T cells in in MPS VI patients.Mestrado em Biomedicina Molecular (Mestrado). Orientador.
2011/03/04. Júri de grau académico. Presentation of lipid antigens to T lymphocytes in patients with Fabry disease. Orientador. Cátia Sofia Oliveira Pereira (Mestrado). Universidade de Aveiro.
2010 - 2011. Orientação. Lipid antigen presentation to T cells in Fabry disease.Mestrado em Biologia Aplicada ramo Biologia Molecular e Celular (Mestrado). Orientador.
2010 - 2010. Comissão de avaliação. Evaluate research projects submitted to the “The Israel Science Foundation (ISF)”.
2009/01/05. Júri de grau académico. MHC class I region in non-alcoholic steatohepatitis. Arguente. Mónica Isabel Encarnação Costa (Mestrado). Universidade de Aveiro.
2009/01/02. Júri de grau académico. Differentiation of T lymphocytes in vitro in the presence of cells infected with Mycobacterium avium. Arguente. Palmira da Conceição de Araújo Barreira da Silva (Mestrado). Universidade de Aveiro.
Projetos
Projetos
2025/01/01 - 2029/12/31. Algarve Biomedical Center Research Institute, Avaliação UID 2023/2024. Universidade do Algarve; Algarve Biomedical Center Research Institute.
2023/09/01 - 2025/08/31. Can Enzyme Replacement Therapy revert iNKT cell dysfunction in Acid Sphingomyelinase Deficiency patients?. Investigador responsável.
2023/03/01 - 2025/02/28. Characterization of invariant Natural Killer T cell phenotype and function in alpha-Galactosidase A deficiency, 3599-PPCDT. Investigador responsável. Universidade do Porto Instituto de Investigação e Inovação em Saúde.
2018/07/15 - 2022/07/14. Structural and functional characterisation of AB toxins targeting antigen-presenting cells and their application as cancer vaccines. Investigador.
2019/01/01 - 2019/12/31. Institute for Research and Innovation in Health Sciences, 6817 - DCRRNI ID. Instituto Nacional de Engenharia Biomédica; Universidade do Porto; Universidade do Porto Instituto de Biologia Molecular e Celular; Universidade do Porto Instituto de Investigação e Inovação em Saúde; Universidade do Porto Instituto de Patologia e Imunologia Molecular.
2016 - 2019. Structured program on bioengineered therapies for infectious diseases and tissue regeneration. Investigador.
2015 - 2019. Characterization of glucosylceramide specific invariant Natural Killer T cells and B lymphocytes in Gaucher disease: implications in disease pathology. Investigador responsável.
2017 - 2017. Antigen presentation in Gaucher disease. Investigador responsável.
2011/03/01 - 2014/11/30. Inter-relações entre os mecanismos patogénicos das Doenças de Sobrecarga Lisosomal e a apresentação de antigénios lipídicos, 5876-PPCDTI. Universidade do Porto Instituto de Biologia Molecular e Celular.
2011/03 - 2014/11. Cross-talk between the pathogenic mechanisms of Lysosomal Storage Diseases and the lipid antigen presentation.. Investigador responsável.
2014 - 2014. The effect of Globotriaosylceramide on invariant Natural Killer T cell activation. Investigador responsável.
2009 - 2013. Enzymatic Replacement treatment for Fabry disease: effect of lymphocyte populations. Investigador responsável.
2011/01/01 - 2012/12/31. Projecto Estratégico - LA 2 - 2011-2012, 6820 - DCRRNI ID. Universidade do Porto Instituto de Biologia Molecular e Celular; Instituto Nacional de Engenharia Biomédica.
2009 - 2012. Modifiers of Hemochromatosis expression: research of new markers of disease progression. . Investigador.
2011 - 2011. Cytokine production by iNKT cells in Fabry disease.. Investigador responsável.
Produções
Freitas, Inês Lua; Macedo, Maria Fátima; Oliveira, Liliana; Oliveira, Pedro; do Vale, Ana; dos Santos, Nuno M.S.. 2025. "AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells". Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1527088
Mondragão-Rodrigues, Inês; Matias, Leonardo; Meireles, Catarina; Macedo, M Fatima. 2025. CD8+ iNKT cells are present in old mice (8 to 12 months) under B6/129 background. Em CiRT meeting (Consortium for iNKT Research and Therapy).
Mondragão-Rodrigues, Inês; Matias, Leonardo; Meireles, Catarina; Macedo, M Fatima. 2025. Invariant natural killer T (iNKT) cells in a-Gal knockout mice. Em 21st International Symposium of the Portuguese Society for Metabolic Disorders (SPDM).
José Pedro Loureiro; M. Fátima Macedo. 2025. "Iron overload impacts TCR ¿d cell immunity". Blood. https://doi.org/10.1182/blood.2025029261
Rajeev Kumar, Sushmitha; Kai He, Khor; Lokanathan, Yogeswaran; Gaurav, Anand; Yusoff, Khatijah; Macedo, M. Fatima; Bhassu, Subha. 2025. "How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus". Frontiers in Immunology, 16. https://doi.org/10.3389/fimmu.2025.1654117
Tiago Fonseca; M. Fátima Macedo. 2024. "Inherited Metabolic Disorders: From Bench to Bedside". Biomedicines. https://doi.org/10.3390/biomedicines12010174
Miranda, Mariana; Mondragão-Rodrigues, Inês; Meireles, Catarina; Macedo, Fatima. 2024. Unveiling iNKT cells in Fabry Disease Patients. Em Sociedade Portuguesa de Imunologia (SPI) Annual Meeting.
Miranda, Mariana; Mondragão-Rodrigues, Inês; Meireles, Catarina; Macedo, Fatima. 2024. iNKT cells in Fabry Disease Patients: from bench to bedside. Em Simpósio da Sociedade Portuguesa de Doenças Metabólicas.
Ribeiro, Camila; Ferreirinha, Pedro; Landry, Jonathan J. M.; Macedo, Fátima; Sousa, Laura G.; Pinto, Rute; Benes, Vladimir; Alves, Nuno L.. 2024. "Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development". Cell Death & Disease, 15 (5). https://doi.org/10.1038/s41419-024-06728-0
Borges SM; Santos C; Macedo MF. 2023. "Monocyte antigen-presenting capacity to iNKT cells is influenced by the blood collection conditions.". Journal of immunological methods. https://doi.org/10.1016/j.jim.2023.113426
Inês Mondragão-Rodrigues; M. Fátima Macedo. 2023. "Buffy Coat Processing Impacts on Monocytes’ Capacity to Present Lipid Antigens". Biomedicines. https://doi.org/10.3390/biomedicines11030833
Olga Amaral; Mariana Martins; Ana Rita Oliveira; Ana Joana Duarte; Inês Mondragão-Rodrigues; M. Fátima Macedo. 2023. "The Biology of Lysosomes: From Order to Disorder". Biomedicines. https://doi.org/10.3390/biomedicines11010213
Nuno Lopes; M Luz Maia; Cátia S. Pereira; Inês Mondragão-Rodrigues; Esmeralda Martins; Rosa Ribeiro; Ana Gaspar; et al. 2023. "Leukocyte Imbalances in Mucopolysaccharidoses Patients". Biomedicines. https://doi.org/10.3390/biomedicines11061699
Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. 2023. The NF-kB targeting toxin AIP56 has tropism for myeloid cells. Em ETOX 2023-EUROPEAN WORKSHOP ON BACTERIAL PROTEIN TOXINS, June 25 - June 29 2023, Crieff, UK.
Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. 2023. Cellular Specificity of AIP56, a Bacterial Toxin that Targets NF-¿B. Em XLVIII Annual Meeting of the Portuguese Society for Immunology, 29-31 March 2023, Aveiro, Portugal.
Freitas, Inês Lua; Macedo, M Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. 2023. AIP56 Has Tropism for Myeloid Cells . Em 9th McBiology Symposium, 23rd and 24th February 2023, i3S, Porto, Portugal.
Freitas, Inês Lua; Macedo, Fatima; Oliveira, Liliana; do Vale, Ana; dos Santos, Nuno M.S.. 2023. Cellular Specificity of AIP56, a Bacterial Toxin that Targets NF-kB. Em I ImmunoHUB Annual Meeting - Infection & Immunity. i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Miranda, Mariana; Macedo, Fatima. 2023. Characterization of invariant Natural Killer T cell phenotype and function in Fabry disease patients. Em Investigação Jovem da Universidade do Porto.
Mariana S. Cruz; José Pedro Loureiro; Maria J. Oliveira; Maria Fatima Macedo. 2022. "The iNKT Cell–Macrophage Axis in Homeostasis and Disease". International Journal of Molecular Sciences, 23 (3): 1640-1640. https://doi.org/10.3390/ijms23031640
J. Pedro Loureiro; Mariana S. Cruz; Ana P. Cardoso; Maria J. Oliveira; M. Fátima Macedo. 2022. "Human iNKT Cells Modulate Macrophage Survival and Phenotype". Biomedicines, 10 (7): 1723-1723. https://doi.org/10.3390/biomedicines10071723
Mondragão-Rodrigues, Inês; Borges, Sofia M; Macedo, M Fatima; Cláudia Santos. Autor correspondente: Macedo, M Fatima. 2022. Monocyte function: the effect of different Buffy Coat processing and blood preservatives.. Em XLVII Sociedade Portuguesa Imunologia Annual Meeting 2022.
Mondragão-Rodrigues, Inês; Borges, Sofia M; Macedo, M Fatima. Autor correspondente: Macedo, M Fatima. 2022. Effects of distinct blood preservatives and processing on monocyte function. Em 15.º Encontro de Investigação Jovem da Universidade do Porto.
Carolina Pinto; Diana Sousa; Vladimir Ghilas; Andrea Dardis; Maurizio Scarpa; Maria Fatima Macedo. 2021. "Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective". International Journal of Molecular Sciences. https://doi.org/10.3390/ijms222312870
H. Ribeiro; M.I. Rocha; H. Castro; M.F. Macedo. 2020. "Chemical inhibition of ß-glucocerebrosidase does not affect phagocytosis and early containment of Leishmania by murine macrophages". Experimental Parasitology, 216: 107939-107939. https://doi.org/10.1016/j.exppara.2020.107939
Pereira, Catia S.; Pérez-Cabezas, Begoña; Ribeiro, Helena; Maia, M. Luz; Cardoso, M. Teresa; Dias, Ana F.; Azevedo, Olga; et al. 2019. "Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients". Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.01264
Espen Melum; Xiaojun Jiang; Kristi D. Baker; M. Fatima Macedo; Jürgen Fritsch; C. Marie Dowds; Jing Wang; et al. 2019. "Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin". Nature Immunology. https://doi.org/10.1038/s41590-019-0504-0
Pereira, C.S.; Ribeiro, H.; Pérez-Cabezas, B.; Cardoso, M.T.; Alegrete, N.; Gaspar, A.; Leão-Teles, E.; Macedo, M.F.. 2018. "The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner". Molecular Genetics and Metabolism, 125 (1-2): 161-167. https://doi.org/10.1016/j.ymgme.2018.07.005
Helena Ribeiro; Catia Pereira; Macedo, M Fatima. 2018. " O potencial imunoterapêutico dos lípidos". Em Bioquímica e Bem Estar. Portugal: Edições Afrontamento.
Belo, R.; Santarém, N.; Pereira, C.; Pérez-Cabezas, B.; Macedo, F.; Leite-de-Moraes, M.; Cordeiro-da-Silva, A.. 2017. "Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and activation". Frontiers in Immunology, 8 (JUN). https://doi.org/10.3389/fimmu.2017.00710
Pereira, C.S.; Ribeiro, H.; Macedo, M.F.. 2017. "From lysosomal storage diseases to NKT cell activation and back". International Journal of Molecular Sciences, 18 (3). https://doi.org/10.3390/ijms18030502
Deng, S.; Kain, L.; Pereira, C.S.; Mata, S.; Macedo, M.F.; Bendelac, A.; Teyton, L.; Savage, P.B.. 2017. "Psychosine variants as antigens for natural killer T cells". Chemical Science, 8 (3): 2204-2208. https://doi.org/10.1039/c6sc04218j
Pereira, C.S.; Macedo, M.F.. 2016. "CD1-restricted T cells at the crossroad of innate and adaptive immunity". Journal of Immunology Research, 2016. https://doi.org/10.1155/2016/2876275
Pereira, C.S.; Sa-Miranda, C.; De Libero, G.; Mori, L.; Macedo, M.F.. 2016. "Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner". European Journal of Immunology, 46 (1): 147-153. https://doi.org/10.1002/eji.201545725
Maia, M.L.; Pereira, C.S.; Melo, G.; Pinheiro, I.; Exley, M.A.; Porto, G.; Macedo, M.F.. 2015. "Invariant Natural Killer T Cells are Reduced in Hereditary Hemochromatosis Patients". Journal of Clinical Immunology, 35 (1): 68-74. https://doi.org/10.1007/s10875-014-0118-0
Quinta, R.; Rodrigues, D.; Assunção, M.; Macedo, M.F.; Azevedo, O.; Cunha, D.; Oliveira, P.; Sá Miranda, M.C.. 2014. "Reduced glucosylceramide in the mouse model of Fabry disease: Correction by successful enzyme replacement therapy". Gene, 536 (1): 97-104. https://doi.org/10.1016/j.gene.2013.11.073
Pereira, C.S.; Azevedo, O.; Maia, M.L.; Dias, A.F.; Sa-Miranda, C.; Macedo, M.F.. 2013. "Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease". Molecular Genetics and Metabolism, 108 (4): 241-248. https://doi.org/10.1016/j.ymgme.2013.01.018
Maia, Maria Luz; Pereira, Catia S.; Ana, Dias F; Rodrigues, Esmeralda; Leão-Teles, Elisa; Sa-Miranda, Clara; Macedo, Fatima. 2013. Lymphocytes and dendritic cells in Mucopolysaccharidosis type VI patients . Em XXXVIII Jornadas Portuguesas de genética.
Pereira, Catia S.; Maia, Maria Luz; Dias, Ana F.; Sa-Miranda, Clara; De Libero, G; Mori, L; Macedo, Fatima. 2013. iNKT Cells in Gaucher and Fabry diseases . Em 7th International Symposium on CD1 and NKT cells.
Dias, Ana F; Pereira, Catia S.; Maia, Maria Luz; Sa-Miranda, Clara; De Libero, G; Mori, L; Macedo, Fatima. 2013. iNKT Cells And Lipid Antigen Presentation In Niemann-Pick Disease Type C . Em 7th International Symposium on CD1 and NKT cells.
Maia, Maria Luz; Pereira, Catia S.; Dias, Ana F; Rodrigues, Esmeralda; Cardoso, Teresa; Martins, Esmeralda; Aguiar, Patrício; et al. 2013. Lymphocytes in Mucopolysaccharidosis type VI patients . Em ESGLD.
Macedo, M.F.; Quinta, R.; Pereira, C.S.; Sa Miranda, M.C.. 2012. "Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model". Molecular Genetics and Metabolism, 106 (1): 83-91. https://doi.org/10.1016/j.ymgme.2012.02.014
Pereira, Catia S.; Maia, Maria Luz; Dias, Ana F.; Vairo, Filippo; Azevedo, Olga; Rodrigues, Esmeralda; Cardoso, Teresa; et al. 2012. Fabry and Gaucher disease patients present specific alterations in invariant Natural Killer T cells . Em XXXVIII Reunião anual da Sociedade Portuguesa de Imunologia.
Catia Pereira; Macedo, M Fatima. 2011. "Lipid antigen presentation to T cells.". Em Current Research in Immunology, 65-78. Vol. 5. Kerala, Índia: Research Media Press.
MacEdo, M.F.; Porto, G.; Costa, M.; Vieira, C.P.; Rocha, B.; Cruz, E.. 2010. "Low numbers of CD8<sup>+</sup>T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8<sup>+</sup>effector memory T cells". Clinical and Experimental Immunology, 159 (3): 363-371. https://doi.org/10.1111/j.1365-2249.2009.04066.x
Balreira, A.; Macedo, M.F.; Girão, C.; Rodrigues, L.G.; Oliveira, J.P.; Sá Miranda, M.C.; Arosa, F.A.. 2008. "Anomalies in conventional T and invariant natural killer T-cell populations in Fabry mice but not in Fabry patients". British Journal of Haematology, 143 (4): 601-604. https://doi.org/10.1111/j.1365-2141.2008.07380.x
Macedo, M.F.; de Sousa, M.. 2008. "Transferrin and the transferrin receptor: Of magic bullets and other concerns". Inflammation and Allergy - Drug Targets, 7 (1): 41-52. https://doi.org/10.2174/187152808784165162
Maria Graça Porto; Carla Sofia Cardoso; Macedo, M Fatima; Eugénia Cruz. 2008. "Hereditary Hemochromatosis Type I: Genetic, Clinical and Immunological Aspects". Fuchs H (ed) Transworld Research Network.
Macedo, M Fatima. 2006. "Transferrin and T cells in iron overload". Doutoramento.
MacEdo, M.F.; Cruz, E.; Lacerda, R.; Porto, G.; De Sousa, M.. 2005. "Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8<sup>+</sup>T lymphocyte numbers". Blood Cells, Molecules, and Diseases, 35 (3): 319-325. https://doi.org/10.1016/j.bcmd.2005.08.001
Macedo, M.F.; De Sousa, M.; Ned, R.M.; Mascarenhas, C.; Andrews, N.C.; Correia-Neves, M.. 2004. "Transferrin is required for early T-cell differentiation". Immunology, 112 (4): 543-549. https://doi.org/10.1111/j.1365-2567.2004.01915.x
Velders, M.P.; Fatima Macedo, M.; Provenzano, M.; Elmishad, A.G.; Holzhütter, H.-G.; Carbone, M.; Martin Kast, W.. 2001. "Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells". Journal of Cellular Biochemistry, 82 (1): 68-77. https://doi.org/10.1002/jcb.1141
Velders, M.P.; Macedo, M.F.; Provenzano, M.; Elmishad, A.G.; Holzhütter, H.-G.; Carbone, M.; Kast, W.M.. 2001. "Human T cell responses to endogenously presented HLA-A* 0201 restricted peptides of simian virus 40 large T antigen". Journal of Cellular Biochemistry, 82 (1): 155-162. https://doi.org/10.1002/jcb.1148
Macedo, M Fatima. 1999. "Characterization of immunogenic human HLA-A*0201 restricted CTL epitopes of Simian Virus 40". Mestrado.
Macedo MF; Velders MP; Nieland JD; Rudolf MP; Weijzen S; Da Silva DM; Franke A; et al. 1998. "Cellular immunity and immunotherapy against deoxyribonucleic acid virus-induced tumors.". http://europepmc.org/abstract/med/9689811
Rudolf MP; Velders MP; Nieland JD; Franke A; Loviscek K; Weijzen S; Macedo, M Fatima; et al. 1998. "Vaccine design for DNA virus induced cancer". Em Sourcebook on Asbestos Diseases, editado por GA Peters, BJ Peters (Eds.). Charlottesville, Estados Unidos: Lewis Publishing, Reed Elsevier.
Velders MP; Nieland JD; Pierce BM; Macedo, M Fatima; Loviscek K; Mourer J; Kast WM. 1998. "Current status and future perspectives of the immunotherapy of cancer". Em Handbook of Ocular Immunology, 181-203. Países Baixos: Aeolus Press.
Velders, M.P.; Nieland, J.D.; Rudolf, M.P.; Loviscek, K.; Weijzen, S.; De Visser, K.E.; Fatima Macedo, M.; Carbone, M.; Kast, W.M.. 1997. "Identification of peptides for immunotherapy of cancer. It is still worth the effort". Critical Reviews in Immunology, 18 (1-2): 7-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030721436&partnerID=MN8TOARS
