dsimes | Universidade do Algarve

Dina Cristina Fernandes Rodrigues da Costa Simes

Professor associado

Faculdade de Ciências e Tecnologia

Centro de Ciências do Mar

Subsistema

Docentes Universitário

Unidade ID

Centro de Ciências do Mar

Regime

Exclusividade

Vínculo

CT em Funções Públicas por tempo indeterminado

Dina Costa Simes. Completed the PhD in Chemistry in 2003, University of Algarve, Master in Cellular Chemistry in 1997 by University of Algarve, Faculty of Sciences and Technologies and Degree in Technological Chemistry in 1990 by University of Lisbon, Faculty of Sciences. Is Assistant Professor in University of Algarve since 2003 and CEO in GenoGla Diagnostics since 2010. Published 51 articles in international peer-reviewed journals. Has 1 book chapter and 1 patent pending. Supervised 3 PhD thesis, 9 MSc dissertations and 36 LSc/BSc students and trainees. Has received 9 awards. Principal Investigator in 6 projects, Researcher in 17 projects and Supervisor in 3 projects. Research main activity on vitamin K dependent proteins associated with mineralization (cardiovascular, skin and cartilage) as potential biomarkers for ectopic calcification and chronic inflammatory-related diseases as cardiovascular disease (CVD) and osteoarthritis (OA). In vitro and ex vivo human cell culture systems developed as models for diseases functional studies and clinical translation. ELISAs for application in clinical diagnostics. Clinical studies for validation of biomarkers with diagnostics/ prognosis utility. Marine bioactive molecules with potential application in the biomedical field. Starting with the creation, as group leader of the Functional Biochemistry and Proteomics research group (FBP-CCMAR) and GenoGla Diagnostics in 2010, a wide national and international research network was established involving: R&D agreements with Hospitals and Ethical committees: Hospital de Cascais Dr. José de Almeida, Pathology, HPP-Hospital de Santa Maria de Faro, Surgery, Centro Hospitalar de Lisboa Ocidental-Hospital de Santa Cruz, Cardiothoracic surgery e Centro Hospitalar de Lisboa Central, Hospital dos Capuchos, Dermatology, Centro Hospitalar Universitário do Algarve EPE-CHUA, Nephrology, Centro Hospitalar Universitário do Algarve EPE-CHUA, Obstetrics, Centro Hospitalar Universitário do Algarve EPE-CHUA, Orthopedic, Delegação do Sul do Instituto Nacional de medicina Legal e ciências Forenses-INMLCF, Complejo Hospitalario Universitario de A Corunã, Corunha, Spain. R&D agreements with national/international Institutions: Cardiovascular Research Institute Maastricht-CARIM, Netherlands; Maastricht University Medical Centre, Netherlands; Centre Européen de Recherche en Biologie et Médecine-IGBMC, France; University Hospital Erlangen, Department of Medicine 3-Rheumatology and Immunology, Germany; Universidade NOVA de Lisboa, Portugal ; Egas Moniz-CiiEM, Portugal; Departamento de Ciências Biomédicas e Medicina, University of Algarve, Portugal;VIB-UGent Center for Medical Biotechnology, Belgium; Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain ; Facultad de Ciencias del Mar y Ambientales, Cádiz, Spain; Clinical Science Technology and Intervention, Karolinska Institutet, Departement of Renal Medicine, Sweden, Stazione Zoologica "A. Dohrn", Naples, Itália, Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain. R&D agreements agreements with national/international companies: Necton, Portugal, VitaK BV, Holanda, Keypoint Group, Portugal, Kintsugi Therapeutics, Spain, Convergence Partners AG, Switzerland.

Atividades

2025/02/01 - Presente. Orientação. Algae Alchemy: Transforming Microalgae into MicroAlgae Cosmetic Extracts (MACE) for a Sustainable Cosmetic Revolution_2024.03327.BDANA.Ciências Biotecnologicas (Doutoramento). Coorientador.

Membro de associação. Associação PNEV- Portuguese Network on Extracellular vesicles. Board member_ Treasurer.

2023/04/01 - Presente. Orientação. Engineered Extracellular Vesicles (EVs) loaded with Gla-Rich Protein (GRP) as nanotherapeutics for cardiovascular and chronic kidney diseases. 2022.12777.BD.Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (Doutoramento). Orientador.

Membro de associação. European Society of Marine BIotechnology. Society member.

2022 - Presente. Orientação. Search for novel macroalgae-derived dietary supplements with anti-inflammatory and antioxidant activity. .Qualidade em Análises (Mestrado). Orientador.

2021/04/01 - Presente. Orientação. Studies towards the establishment of Gla-rich protein as a biomarker for cardiovascular risk assessment. 2020.07476.BD
.Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (Doutoramento). Orientador.

2021/03/10 - Presente. Comissão de avaliação. Review Editor on the Editorial Board of Marine Biotechnology (specialty section of Frontiers in Marine Science and Frontiers in Bioengineering and Biotechnology)..

2020/04/27 - Presente. Outro júri / avaliação. Topic Board Member of the international peer-reviewed open access journal Molecules (MDPI) .

Membro de associação. COST ACTION European transdisciplinary networking platform for marine biotechnology (Ocean4Biotech) CA18238. Working Group Participant.

2019/11/27 - Presente. Membro de comissão. The Portuguese Association of Proteomics- REDE PROCURA .Board Member.

Membro de associação. Rede ProCura - Portuguese Proteomics Association: Lisbon, PT. Treasurer (Society Board Member).

Membro de associação. Rede Procura- Assocoiação Portuguesa de Proteómica. Board member_ Treasurer.

Membro de associação. Portuguese Network on Extracellular Vesicles. Member .

Membro de associação. Portuguese Network on Extracellular Vesicles: Porto, PT. Member.

2018/11/27 - Presente. Outro júri / avaliação. International External evaluator and reviewer for an International Doctor Title “Standardization of platelet rich plasma as a drug for osteoarthritis" Lucía Gato Calvo, PhD student, Rheumatology Researh Group, at the Biomedical Research Institute of A Coruña (INIBIC). .

2018 - Presente. Orientação. Extracellular vesicles in cardiovascular therapeutics. . Orientador.

2016/12 - Presente. Orientação. Interplay between mineralization and inflammation in vascular calcification and osteoarthritis: extracellular vesicles and marine bioactive compounds as new therapeutic approaches. SFRH/BD/111824/2015.Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (Doutoramento). Orientador.

2021/09/06. Entrevista (jornal / revista). RTP3 Algas invadem praias algarvias

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2021/09/04. Entrevista (jornal / revista). Algas asiáticas invadem Algarve, RTP Online .

2021/09/01. Entrevista (jornal / revista). Plataforma Digital Algas na Praia apresenta dados obtidos com a colaboração dos cidadãos Voz do Algarve Online .

2021/09/03. Entrevista (jornal / revista). Algas em praias do Algarve RTP1 - Portugal em Direto

.

2021/08/03. Entrevista (jornal / revista). Algas nas praias do Algarve incomodam banhistas, TVI jornal das 8, Repetições: TVI24 - Jornal das 8 , 2021-08-03 21:25 TVI24 - Notícias

.

2021/08/10. Entrevista (jornal / revista). Plataforma vai monitorizar acumulação de algas nas praias DiáriOnline - Região Sul Online .

2026/05/20 - 2026/05/22. Organização de evento. ProteoVilamoura 2026- 6th Joint Meeting of the Portuguese, Spanish and French Proteomics Societies, 20-22 May, Vilamoura, Portugal (2026). REDE PROCURA-ASSOCIAÇÃO PORTUGUESA DE PROTEÓMICA.

2026/03/06. Júri de grau académico. Exploring the Photoprotective Potential of Natural Compounds: Insights into UV-induced Oxidative Stress Modulation. Vogal. Alessia Luccarini (Doutoramento). Università Politecnica delle Marche.

2026/02/13. Júri de grau académico. Modeling Idiopathic Pulmonary Fibrosis from 2D to 3D cultures: Functional characterization of AGR2-related pathways in human lung models. Vogal. Di Palma Rosita (Doutoramento). Università degli Studi di Napoli Federico II.

2025/12/16. Apresentação oral de trabalho. Circular Blue Bioeconomy and sustainable marine-based solutions.. Greencolab (Faro, Portugal).

2025/06/26 - 2025/06/27. Organização de evento. 3RD Meeting of the Portuguese Network on Extracellular vesicles, Universidade do Algarve Campus de Gambelas (2025).

2025/06/23. Apresentação oral de trabalho. Exploring the therapeutic application of Gla-rich protein (GRP) in chronic inflammatory diseases using bioengineered nanovesicles. PORTUGUESE NETWORK OF EXTRACELLULAR VESICLES (PNEV) (Faro, Portugal).

2024/01/15 - 2024/07/31. Orientação. Exploring Algae for new anti-inflammatory and antioxidant bioactives with potential application in chronic inflammatory diseases.IMBRSea Master program (Mestrado). Orientador.

2023/09/09 - 2024/02/02. Orientação. Exploring Human-derived extracellular vesicles (EVs) loaded with human GRP as new anti-inflammatory nanoformulations.Projeto Cientifico 12 ECTS (Licenciatura/Bacharelato). Coorientador.

2023/09/15 - 2024/02/01. Orientação. EXPLORING VITAMIN K1 AS NOVEL THERAPEUTIC PREVENTION STRATEGY FOR OSTEOARTHRITIS..Projeto cientifico 12 ECTS (Licenciatura/Bacharelato). Coorientador.

2023/09/15 - 2024/02/01. Orientação. Exploração do potencial de extratos de macroalgas e da Vitamina K como antioxidantes e anti-inflamatórios para novos suplementos alimentares. .Projeto Cientifico 12 ECTS (Licenciatura/Bacharelato). Orientador.

2024. Júri de grau académico. Interplay between mineralization and inflammation in vascular calcification and osteoarthritis: extracellular vesicles and marine bioactive compounds as new therapeutic approaches.. Orientador. Nuna Araújo (Doutoramento). Universidade do Algarve.

2023/07/14 - 2023/07/14. Organização de evento. Nutrisafe Workshop - Valorisation of invasive seaweed biomass to develop new products for the blue bioeconomy (2023). Universidade do Algarve.

2023/07/14. Apresentação oral de trabalho. Exploring invasive macroalgae as a biomass source for a novel and sustainable vitamin K1 diet supplement. . Nutrisafe Workshop-Valorisation of invasive seaweed biomass to develop new products for the blue bioeconomy . Universidade do Algarve (Faro, Portugal).

2023/07/05. Apresentação oral de trabalho. Vitamin K intake and Mediterranean Diet: preliminary results of a Portuguese populational survey. CiiEM-Egas Moniz (Monte da Caparica, Portugal).

2023/06/14. Apresentação oral de trabalho. In vitro studies for screening and validation of relevant bioactivities from algae-derived products. Universidade do Algarve (Faro, Portugal).

2023/06/14. Apresentação oral de trabalho. Vitamin K intake and Mediterranean Diet: preliminary results of a Portuguese populational survey. Universidade do Algarve (Faro, Portugal).

2022/12/07. Apresentação oral de trabalho. Preclinical studies to validate novel therapeutics to prevent and treat chronic inflammatory diseases associated with ageing. International Conference Aging without Borders. ABCRI (Faro, Portugal).

2022/09/22. Apresentação oral de trabalho. Preclinical studies of bioactive compounds using human in vitro/ex vivo models to advance drug development. International Summer School of Blue Biotechnology (ISSBB). Stazione Zoologica Anton Dohrn of Naples (Naples, Itália).

2021 - 2022/07/01. Orientação. Marine-derived vitamin K as a natural supplement with anti-inflammatory and vascular protective properties. .Biologia Molecular e Microbiana (Mestrado). Orientador.

2022/06/27. Apresentação oral de trabalho. Extracellular vesicles in cardiovascular diseases. Extracellular Vesicles in Noncommunicable Diseases. CiiEM-Egas Moniz (Monte da Caparica, Portugal).

2022/06/11 - 2022/06/11. Entrevista / Programa (rádio / tv). CNN Portugal Primeiro Jornal. Investigadores do Algarve querem dar uma nova vida às algas através de suplementos alimentares.

2022/05/11 - 2022/05/13. Organização de evento. Congress organization: ProteoVilamoura, 2nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies, 11th to 13th May 2022, Vilamoura, Portugal (https://proteo-vilamoura.sci-meet.net/). (2022).

2021/10/04 - 2022/02/28. Orientação. Enzyme-Linked Immunosorbent Assay (ELISA) for detection and quantification of specific proteins. .Laboratory methods B 3 ECTS. Orientador.

2021/07/01 - 2022/02/28. Orientação. Master fellowship BI_ Projeto 72583 NutriSafe: Explorando um novo e sustentável suplemento alimentar de origem marinha na promoção da longevidade e qualidade de vida em tempos de pandemia”
Universidade do Algarve, financiado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do Programa Operacional CRESC Algarve 2020, do Portugal2020, 6 months. Titulo:

. Orientador.

2022/02/22. Júri de grau académico. The calcium paradox – the role of vitamin K on the bone-vascular
axis. Arguente. Grzegorz B. Wasilewski (Doutoramento). Universiteit Maastricht.

2021/10/04 - 2022/02/19. Orientação. Exploração de novos compostos bioativos como agentes anti-inflamatórios e anticalcificantes com potencial aplicação em doenças inflamatórias crónicas (CID). Projeto 12 ECTS.Bioquímica (Outra). Orientador.

2021/10/04 - 2022/02/19. Orientação. Purification and characterization of human Gla rich protein (GRP) overexpressed in the E.Coli system. PLACEMENT 6 ECTS.Biologia Molecular e Microbiana (Outra). Orientador.

2021/02/01 - 2021/12/31. Outro júri / avaliação. Guest Editor for Special Issue on " Vitamin K and Vitamin K-Dependent Proteins in Homeostasis and Pathology " in the International Journal of Molecular Sciences (Impact Factor 4.556). .

2020/01/23 - 2020/01/23. Participação em evento. Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças, Escola Dr. Francisco Fernandes Lopes, Olhão – 12º ano. Seminário. Projeto Cientificamente provável, Ministério da Ciência e Ensino Superior. Universidade do Algarve; Centro de Ciências do Mar.

2021 - 2021/07. Orientação. Methods for the study of Gla-rich protein (GRP) in vascular calcification and inflammation..Biologia (Licenciatura/Bacharelato). Orientador.

2021/03/09 - 2021/04/16. Orientação. Madeira, Helena (2021). Estudo do potencial anti-inflamatório cutâneo de novos componentes obtidos a partir de algas marinhas. Modulo de Escolha do Estudante 1 (8 ECTS), Integrated Master in Medicine - UAlg.Medicine (Mestrado). Orientador.

2020/12/18. Apresentação oral de trabalho. The role of EVs in physiological and pathological calcification. i3S (Porto, Portugal).

2020/09/22 - 2020/10/13. Outro júri / avaliação. Avaliador projetos de investigação do Sistema de Incentivos (ANI)..

2019 - 2020/09/10. Orientação. Preclinical studies for development and testing of dermocosmetics from marine origin..Mestrado integrado em ciencias farmaceuticas (Mestrado). Orientador.

2020/06/06. Apresentação oral de trabalho. Gla-rich protein (GRP) as an early and novel marker associated with vascular calcification and CKD-Mineral and Bone Disorder (MBD) in diabetic patients with CKD: A pilot cohort study. ERA-EDTA.

2015 - 2020. Outro júri / avaliação. Reviewer for International Journals:The Journal of Physiology
Endokrynologia Polska
Thrombosis and Haemostasis
ATVB
PlosONE
Molecules
Antioxidants
Circulation Journal
FEBSOpen Bio
International Journal of Biological Macromolecules
Histology and Histopathology
Theranostics
IJMS
Journal of Cellular and Molecular Medicine
Journal of Extracellular Vesicles
Food & Function
International Journal of Nephrology and Renovascular Disease
British Journal of Pharmacology
Nutrients
Acta Biomaterialia
.

2019/12/03. Apresentação oral de trabalho. ALGARED+: Old and new microalgae for novel bioactivities. . ALGAEUROPE 2019. ALGAEUROPE 2019 (Paris, França).

2019/11/22. Apresentação oral de trabalho. Round table “Aplicações da biomassa de algas. Workshop ALGAS – Investigação, inovação, sustentabilidade e estímulo à bioeconomia circular. . AlgaRed+ (Faro, Portugal).

2019/10/18. Apresentação oral de trabalho. New advances on Gla Rich Protein (GRP) as a clinical utility biomarker for cardiovascular risk assessment in chronic kidney disease . Sinal 2019-10th Meeting on signal Transduction, . 10th Meeting on signal Transduction (olhão).

2019/09/16. Apresentação oral de trabalho. Treating old diseases with new bioactive compounds obtained from marine resources. Seminário Biotecnologia azul, 1 ciclo de gestão marinha e costeira,. Universidade do Algarve (fa, Portugal).

2019/09/01. Apresentação oral de trabalho. Amentadione, a meroditerpenoide from brown algae with capacity of modulating osteoarthritic responses, in a close-to-in-vivo OA model. . Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products,. XVI MANAPRO & XI ECMNP (Peniche, Portugal).

2019/06/02. Apresentação oral de trabalho. Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP). . 4th congress of CiiEM-Health, Well-Being and Ageing in the 21st Century. CiiEM (Monte da caparica, Portugal).

2019/03/26. Apresentação oral de trabalho. Anti-inflammatory and dermoprotective activity of a selection of microalgae extracts. Workshop AlgaRed+, I seminário Projeto ALGARED+ Novas microalgas, novas aplicações. Universidade do Algarve (Faro, Portugal).

2019/02/21 - 2019/02/21. Participação em evento. Vamos encontrar novos fármacos e cosméticos de origem marinha para tratar doenças e travar o envelhecimento!. Seminário. Dia Aberto UAlg 2019. Universidade do Algarve.

2019 - 2019. Orientação. Extraction of anti-inflammatory drugs form Microalgae. .WATER AND COASTAL MANAGEMENT - ERASMUS MUNDUS (Mestrado). Coorientador.

2019 - 2019. Orientação. Gla-rich protein, a marker for calcification propensity in diabetic with chronic kidney disease. Modulo de escolha do Estudante, Mestrado Integrado em Medicina , UAlg. Orientador.

2019 - 2019. Orientação. Testing the therapeutic potential of Gla Rich Protein-chitosan-tripolyphosphate nanoparticles for osteoarthritis using an ex-vivo co-culture preclinical assay. .Modulo escolha do Estudante, Departamento de Ciências Biomédicas e medicina (Iniciação científica). Orientador.

2018/11/08. Apresentação oral de trabalho. Amentadione from the alga Cystoseira Usneoides - potential application in osteoarthritis therapeutics. Seminário Biotecnologia Azul, 1 ciclo Gestão marinha e Costeira. Universidade do Algarve-FCT (Faro, Portugal).

2018/10/13. Apresentação oral de trabalho. Gla-rich Protein (GRP): A new player in the burden of vascular Calcification – clinical implications . Núcleo de Biologia Vascular da SPACV. SPACV (Ilhavo, Portugal).

2018/07/15 - 2018/08/05. Outro júri / avaliação. Summer School SHOU, 2018. "Bioactivity of marine compounds". FBP-CCMAR (Laboratório anfitrião) Supervised 3 PhD students from SHOU University. Duração: 15/07/2018 a 05/08/2018.
. Centro de Ciências do Mar.

2018/06/20. Apresentação oral de trabalho. Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay. . 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences. CiiEM (Monte da Caparica, Portugal).

2018/06/20. Apresentação oral de trabalho. Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP). . 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences. CiiEM (Monte da Caparica, Portugal).

2018/03/22. Apresentação oral de trabalho. Gla-Rich Protein como um novo marcador de calcificações vasculares numa população de diabéticos com doença renal crónica. . Encontro Renal 2018, XXXII Congresso SPN. Sociedade Portuguesa de Nefrologia (Vilamoura, Portugal).

2018 - 2018. Orientação. Study the role of GRP produced by inflammatory cells in mediating VSMCs inflammation. Orientador.

2018 - 2018. Orientação. Study the association of Gla-rich protein (GRP) with urinary extracellular vesicles (EVs) and chronic kidney disease (CKD).. Orientador.

2018 - 2018. Orientação. Testing the anti-inflammatory potential of Gla Rich Protein nanoparticles for its use in therapeutics. . Orientador.

2018 - 2018. Outro júri / avaliação. Expert and evaluator of one project proposal for the French ATIP-Avenir program 2018 organized by CNRS and INSERM. .

2018. Júri de grau académico. Farmacogenómica da Depressão.. Arguente principal. Sarah Marques da Silva Patel (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017/11/04. Apresentação oral de trabalho. Gla-rich Protein (GRP) is a New Therapeutic Target for Chronic Kidney Disease. PCS 4th World Congress of Cardiothoracic-renal Diseases “Bridging Basic Research and Clinical Practice. PCS 4th World Congress of Cardiothoracic-renal Diseases (Lisboa, Portugal).

2010/10/01 - 2017/09/01. Tutoria. Studies for the establishment of GRP as a biomarker for ectopic calcifications. Insights into the role of GRP in tumoral processes. (SFRH/BPD/70277/2010 Postdoctoral fellowship). Carla Alexandra São Bento Viegas.

2017/07/09 - 2017/08/01. Outro júri / avaliação. Summer School SHOU, 2017. "Testing marine bioproducts as potential novel cosmetics". FBP-CCMAR. Supervised 3 PhD students from SHOU University Duração: 09/07/2017 a 01/08/2017. Orientação: Viegas, CSB, Araújo, N, Simes, DC. Centro de Ciências do Mar.

2017/06/28. Apresentação oral de trabalho. Unveiling the dual role of Gla-rich protein (GRP) in the crosstalk between inflammation and calcification in pathological processes. Seminários CCMAR. CCMAR (Faro, Portugal).

2017/06/11 - 2017/06/13. Organização de evento. 2º Congresso Internacional do CiiEM - Translational Research and Innovation in Human and Health Sciences. (2017). Centro de Investigação Interdisciplinar Egas Moniz.

2017/06/11. Apresentação oral de trabalho. Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases. 2º Congresso Internacional do CiiEM - Translational Research and Innovation in Human and Health Sciences. CiiEM.

2017/06/03. Apresentação oral de trabalho. Circulating calciprotein particles and extracellular vesicles as novel players in chronic kidney disease vascular calcification: a role for Gla-rich protein. ERA-EDTA 54th Annual Congress. ERA-EDTA (Madrid, Espanha).

2013/01/01 - 2017/03/03. Orientação. The application of 2D-DIGE proteomics to human articular cartilage. A new approach for the identification of osteoarthritis biomarkers. SFRH/BD/60867/2009.Ciências Biológicas (Doutoramento). Orientador.

2017/03/01 - 2017/03/01. Participação em evento. Como podem as proteínas dizer-nos se estamos doentes?, 5ª edição projeto Mitose: Ciência a Sul 2017, Participação de 2 estudantes 11º ano Escola secundária de Manteigas: Duarte Carvalhinho (1º prémio) Matilde Costa (Menção honrosa), CCMAR/Universidade do algarve, Faro, Portugal 01/03/2017. Oficina (workshop). 5ª edição projeto Mitose: Ciência a Sul 2017. Universidade do Algarve.

2017 - 2017. Orientação. Bioactive marine compounds as novel therapeutics in osteoarthritis.Ciências Biomédicas (Mestrado). Orientador.

2017 - 2017. Orientação. Clinical application of extracellular vesicles in vascular calcification.Ciências Farmacêuticas (Mestrado). Orientador.

2017 - 2017. Orientação. In vitro studies to determine the role of fetuin-mineral complex in the calcification stress in CKD. Subject . Orientador.

2017 - 2017. Orientação. Can we use the tissues obtained from OA patients to set up a 3D in vitro model for the study of osteoarthritis? . Orientador.

2017. Júri de grau académico. Farmacogenómica do cancro colo-retal.. Arguente principal. Barbara Filipa Ascenso Marrucho (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Aplicação de péptidos marinhos na terapia oncológica.. Arguente principal. Cláudia Isabel Tomé Reis (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Diabetes mellitus Tipo 2 como Doença Inflamatória: anatomia, fisiopatologia e terapêutica, . Arguente principal. Maria Romanciuc (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Clinical application of extracellular vesicles in vascular calcification. . Orientador. Catarina Isabel Lousada Marreiros (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Influência da farmacogenómica na terapêutica da artrite reumatoide. . Arguente principal. Inês carolina Ribeiro de Oliveira (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Marine Algae extracts as a source of natural antileishmanial compounds. . Arguente principal. Carolina Amaral Frade Bruno de Sousa (Doutoramento). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2017. Júri de grau académico. Marine Algae extracts as a source of natural antileishmanial compounds. . Arguente. Carolina de Sousa (Doutoramento). Universidade do Algarve - Campus de Gambelas.

2013 - 2017. Orientação. STUDIES TOWARDS UNVEILING THE ASSOCIATION OF GLA-RICH PROTEIN WITH OSTEOARTHRITIS.Ciências Biológicas (Doutoramento). Orientador.

2016/11/21 - 2016/11/21. Curso / Disciplina lecionado. Semana da Ciência, Agrupamento de Escolas Pinheiro e Rosa, Faro. Explorar o mar para encontrar novos fármacos e suplementos alimentares que melhoram a nossa saúde.. Universidade do Algarve.

2016/07/12 - 2016/07/12. Participação em evento. Vamos tornar as células humanas fluorescentes!. Seminário. Cursos de Verão 2016, CCMAR/ Universidade do Algarve. Universidade do Algarve.

2016/07/11. Apresentação oral de trabalho. Dysregulated fetuin-mineral complexes are linked to vascular calcification in chronic kidney disease: the role of Gla-rich protein. Ultrapath XVII, Society for Ultrastructural Pathology. Society for Ultrastructural Pathology (Lisboa, Portugal).

2016/06/08. Apresentação oral de trabalho. Exploring the sea for novel drugs to treat old diseases. Seminarios CCMAR. CCMAR.

2016/05/05. Apresentação oral de trabalho. Marine bioactive compounds: testing novel drugs for old desiases. IX Xornada Cientifica Terapia Celular e medicina regenerativa. CICA, Campus de Elviña (Coruña).

2016/04/04 - 2016/04/05. Organização de evento. Exploitation and Legal Aspects on Marine Genetic and Chemical Resources (2016). Consiglio Nazionale delle Ricerche Area di Ricerca di Napoli 1.

2016/04/04. Apresentação oral de trabalho. In vitro testing of bioactive compounds: a bridge to clinical trials and industrial application. EuroMarine Meeting entitled “Exploitation and Legal Aspects on Marine Genetic and Chemical Resources. Institute of Protein Biochemistry, CNR Research Area (Naples, Itália).

2016/02/25. Apresentação oral de trabalho. Centre of Marine Sciences (CCMAR) – Central de Serviços e Tecnologia do CCMAR . Sessão Transfronteiriça de Divulgação de Serviços I&DT na Área da Saúde. CRIA – Divisão de Empreendedorismo e Transferência de Tecnologia e Escola Superior de Saúde (Faro, Portugal).

2013/01/01 - 2016/01/01. Tutoria. Gla rich protein (GRP) role in human vascular calcification. (SFRH/BPD/89188/2012 PostDoctoral Fellowship). Marta Sofia Rafael.

2016 - 2016. Orientação. The role of vitamin K in osteoarthritis.Ciências Farmacêuticas (Mestrado). Orientador.

2016 - 2016. Outro júri / avaliação. Reviewer and evaluator of research project proposal submitted to the Dutch Arthritis Foundation (Reumafonds).

2016. Júri de grau académico. The role of vitamin K in osteoarthritis.
. Orientador. Carla Margarida da Silva Pereira (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2016. Júri de grau académico.
Farmacogenómica do cancro da mama.. Arguente principal. Beatriz Rosário Santos Sousa (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2016. Júri de grau académico. Aplicação de fitoterapia como terapêutica coadjuvante e preventiva das doenças inflamatórias intestinais: Colite Ulcerosa e Doença de Crohn.. Arguente principal. Ana Catarina Prates Felismino (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2015/12/15 - 2015/12/15. Organização de evento. New, High Throughput Tools and Methods for Label-Free Characterization of Biotherapeutic Molecules. (2015). Centro de Ciências do Mar.

2015/12/02 - 2015/12/02. Organização de evento. Nanoparticles characterization by NTA-Nanoparticle tracking analysis; concepts and applications by Paralab (2015). Centro de Ciências do Mar.

2015/09/21 - 2015/09/25. Organização de evento. Biomedical and biological applications of scanning and transmission electron microscopy” (2015). Centro de Ciências do Mar.

2014/01/20 - 2014/01/20. Curso / Disciplina lecionado. Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças - Escola Dr. Francisco Fernandes Lopes – Olhão – 12º ano. Projeto rede de partilha científica, CCVIVA – Agência Nacional para a Cultura Científica e Tecnológica, Portugal.. Centro de Ciências do Mar.

2015/07/06 - 2015/07/17. Participação em evento. Como pode o investigador ajudar o médico no diagnóstico da doença osteoartrite?. Oficina (workshop). Ocupação Científica de Jovens no Verão, Estágios CCVIVA Verão. Universidade do Algarve.

2015/07/07 - 2015/07/07. Participação em evento. Como se faz o diagnóstico de doenças no laboratório. Seminário. Cursos de Verão 2015 CCMAR/UAlg. Universidade do Algarve.

2015/07/01 - 2015/07/03. Organização de evento. Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2015). Centro de Ciências do Mar.

2015/06/30 - 2015/06/30. Participação em evento. Vamos tornar as células humanas fluorescentes! . Seminário. Dia Aberto UAlg 2015. Universidade do Algarve.

2015/04/30 - 2015/04/30. Participação em evento. Dia Aberto Escola Secundária de Vila Real de Santo António, Como pode a histologia ajudar os médicos no diagnóstico? . Seminário. Dia Aberto Escola Secundária de Vila Real de Santo António, Como pode a histologia ajudar os médicos no diagnóstico? . Universidade do Algarve.

2015/02/26 - 2015/02/26. Participação em evento. Vamos tornar as células humanas fluorescentes! . Seminário. Dia Aberto UAlg. Universidade do Algarve.

2015 - 2015. Orientação. Cultivation techniques of THP-1 cell line, isolation of extracellular vesicles and characterization of its components. .Biologia (Iniciação científica). Orientador.

2015 - 2015. Orientação. Gla-Rich-Protein (GRP): a Novel Vitamin K-Dependent Protein, with potential to interfere with the dynamics of basic-calcium phosphate (BCP) crystals formation.Bioquímica (Iniciação científica). Orientador.

2015 - 2015. Tutoria. CCMAR/BI/0020/2014 (2015) . Lúcia Santos.

2015 - 2015. Tutoria. CCMAR/BI/0018/2015 (2015). Nuna Araújo.

2015 - 2015. Tutoria. CCMAR/BI/0005/2015 (2015) . Nuna Araújo.

2015. Apresentação oral de trabalho. New targets for therapeutics in osteoarthritis: Marine compounds and Gla rich proteins. 9th SFRR-Africa/4th IAMBR conference. Translational Science and Drug Discovery: Impact on Health, Wellness, Environment and Economics. 9th SFRR-Africa/4th IAMBR conference (Maurícias).

2014/11/24 - 2014/11/24. Curso / Disciplina lecionado. Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças - Escola D. Martinho Castelo Branco – Portimão – 8º e 9º ano - Projeto rede de partilha científica, financiado pela CCVIVA – Agência Nacional para a Cultura Científica e tecnológica, Portugal.. Centro de Ciências do Mar.

2014/07/02 - 2014/07/04. Organização de evento. Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2014). Centro de Ciências do Mar.

2014 - 2014. Orientação. Interaction studies of Gla-rich protein with bone morphogenetic proteins.Ciências Biomédicas (Mestrado). Orientador.

2014 - 2014. Orientação. Calcified aortic valve and aortic rings: what’s the role of Gla-rich protein? .Modulo escolha do Estudante, Departmento de Medicina (Iniciação científica). Orientador.

2014. Júri de grau académico. Salt marsh plants as source of bioactive compounds.. Arguente principal. Maria Isabel Rocha (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2013 - 2014. Tutoria. CCMAR/BI/0005/2013 (2013-2014). Sofia Santos.

2013/07/01. Apresentação oral de trabalho. GRP/Ucma: a potential novel vitamin K-dependent protein, involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells.. XXIV Congress of the International Society on Thrombosis and haemostasis (ISTH). INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS (Amesterdam, Países Baixos).

2013/06/29. Apresentação oral de trabalho. GRP/Ucma: a potential novel vitamin K-dependent protein, involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells.. XXIV Congress of the International Society on Thrombosis and haemostasis (ISTH). International Society on Thrombosis and haemostasis (Amsterdam, Países Baixos).

2013/03/20 - 2013/03/20. Curso / Disciplina lecionado. Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças, Escola Secundária José Belchior Viegas – São Brás de Alportel - 12º ano. Projeto rede de partilha científica, financiado pela CCVIVA – Agência Nacional para a Cultura Científica e Tecnológica, Portugal.. Centro de Ciências do Mar.

2013 - 2013. Orientação. STUDY OF THE ASSOCIATION OF GLA RICH PROTEIN (GRP) TO HUMAN BLOOD CELLS.Ciências Biomédicas (Mestrado). Orientador.

2013 - 2013. Orientação. GRP gene expression in different mouse tissues. Orientador.

2013. Júri de grau académico. Study of the association between Gla Rich Protein (GRP) and human blood cells.. Orientador. Ruben Costa (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2012 - 2013. Tutoria. CCMAR/BI/0031/2012 (2013). Inês Luis.

2012/12/06. Apresentação oral de trabalho. O Farmacêutico empreendedor em meio Universitário. Start-ups. III Colóquio NECiFarm. NECiFarm (Faro, Portugal).

2012/07/11 - 2012/07/12. Organização de evento. Workshop on “Strategies for recombinant protein production” (2012). Centro de Ciências do Mar.

2012/07/04 - 2012/07/06. Organização de evento. Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2012). Centro de Ciências do Mar.

2010/01/29. Apresentação oral de trabalho. Study of Gla Rich Protein (GRP) function in pathological calcification processes and its potential for use as a biomarker. IV SPB Clinical Biochemistry Workshop. SPB (Faro, Portugal).

2012 - 2012. Tutoria. CCMAR/BI/0020/2014 (2013-2014) . Inês Luis.

2011 - 2012. Tutoria. CCMAR/BPD/0035/2011 (2011-2012) . Marta Rafael.

2011/10/19. Apresentação oral de trabalho. Papel de uma nova proteína no processo degenerativo da cartilagem articular: resultados preliminares. XXXI Congresso Nacional de Ortopedia e Traumatologia . Congresso Nacional de Ortopedia e Traumatologia (Estoril, Portugal).

2011/07/13 - 2011/07/15. Organização de evento. Three-day course on “Strategies for recombinant protein production”, 13-15 July 2011, CCMAR/UALG, Portugal. (2011). Centro de Ciências do Mar.

2011/07/13. Apresentação oral de trabalho. Applications of recombinant proteins . Three days course on strategies for recombinant protein production. CCMAR (Faro, Portugal).

2011 - 2011. Orientação. Production and purification of human recombinant GRP non-gammacarboxylated.Molecular Biology and Microbiology (Mestrado). Orientador.

2011 - 2011. Orientação. Extraction, purification and characterization of Native GRP from the adriatic sturgeon (Acipenser nacarii). Studies on the protein stability. Orientador.

2011 - 2011. Orientação. Extraction, purification and characterization of recombinant GRP.. Orientador.

2011. Júri de grau académico. Produção e purificação da proteína GRP humana recombinante não gamacarboxilada.
. Orientador. Vera Maria (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2010 - 2011. Tutoria. CCMAR/BI/0019/2010 (2010-2011) . Carla Alexandra São Bento Viegas.

2010 - 2011. Tutoria. CCMAR/BPD/0030/2010 (2011). Carla Viegas.

2010/10/20. Apresentação oral de trabalho. Study of Gla Rich Protein (GRP) and its potential for use as a biomarker of pathological calcification related diseases. Sociedade Portuguesa de Biofísica. SPB (Monte da Caparica, Portugal).

2010/03/21. Apresentação oral de trabalho. Gla Rich Protein (GRP), A New Biomarker For Ectopic Calcifications?. BIT’s 3rd Annual Protein and Peptide Conference. BIT’s (Beijing, China).

2010 - 2010. Orientação. Purification and characterization of Gla Proteins in the teleost and mammalian model..Molecular biology and microbiology (Mestrado). Orientador.

2010 - 2010. Orientação. Study of the relation between Gla containing proteins and Tumors..Ciências Biomédicas (Licenciatura/Bacharelato). Orientador.

2010 - 2010. Orientação. Detection of Gla proteins in Xenopus laevis bone.Bioquímica (Licenciatura/Bacharelato). Orientador.

2010 - 2010. Orientação. Detection of Gla-Proteins with the ability to bind Hidroxyapatite mineral in the heart of Gallus gallus domesticus (chicken)..Bioquímica (Licenciatura/Bacharelato). Orientador.

2010 - 2010. Orientação. A proteomic approach in the isolation and characterization of proteins dependent of Vitamin K present in the skeleton of Blue Shark (Prionace glauca)”(. Orientador.

2010 - 2010. Tutoria. CCMAR/BI/0019/2014 (2014-2015). Rúben Costa.

2010. Júri de grau académico. Purificação e caracterização de proteínas Gla nos modelos peixe e mamífero. . Orientador. Sofia Cavaco (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2010. Júri de grau académico. Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP: Contribution to unveil its function in vertebrates. . Orientador. Carla São-Bento Viegas (Doutoramento). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2005 - 2010. Orientação. Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP: Contribution to unveil its function in vertebrates.Bioquímica (Doutoramento). Coorientador.

2009/10/26. Apresentação oral de trabalho. Aplicações da análise proteomica 2D na identificação de possiveis biomarcadores para diagnóstico/prognóstico de doenças. Seminários CHUAlgarve. CHUAlgarve (Faro, Portugal).

2009/05/27. Apresentação oral de trabalho. Fish as model organisms to uncover new Gla proteins of interest for human biology , 27-29 April, Tavira, Portugal (Cancela ML, invited speaker). Workshop - Interdisciplinary Approaches in Fish Skeletal Biology. Universidade do Algarve (Tavira, Portugal).

2009 - 2009. Orientação. Study of gla containing, vitamin K-dependent proteins associated with skin mineralization pathologies..Ciências Biomédicas (Licenciatura/Bacharelato). Orientador.

2009 - 2009. Tutoria. CCMAR/BI/0020/2011 (2011). Pedro Palma.

2009 - 2009. Tutoria. CCMAR/BI/0039/2013 (2013-2014). Rúben Costa.

2008/11/12. Apresentação oral de trabalho. Identification of an MGP/OC hybrid gene in Adriatic sturgeon (Acipenser naccarii), representing an ancient form of Osteocalcin.. Seminários CCMAR. CCMAR (Faro, Portugal).

2008 - 2008. Orientação. Proteome characterization of nacre obtained from the oyster Crassostrea Gigas.Bioquímica (Licenciatura/Bacharelato). Orientador.

2008. Júri de grau académico. Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress. . Arguente principal. Rita Margarida Ascenso (Doutoramento). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2007/05/03. Apresentação oral de trabalho. Identification of an MGP/OC hybrid gene in Adriatic sturgeon Acipenser naccarii. Seminários Mar e Ambiente. Universidade do Algarve (Faro, Portugal).

2006/05/19. Apresentação oral de trabalho. Molecular cloning and regulation of the genes encoding Matrix and Bone Gla proteins from Sturgeon. Studies towards understanding the evolution of their molecular mechanism of action. Seminários Mar e Ambiente. Universidade do Algarve (Faro, Portugal).

2005/07. Júri de grau académico. Sequential pathology and localization of IPNV by immunohistochemistry in Atlantic Salmon (Salmo salar L.) post-smolts challenge by cohabitation”. Arguente principal. Andreia Margarida Batista Custódio Cavaco (Outro). Universidade do Algarve.

2005/04/21. Apresentação oral de trabalho. Gla Proteins from bone and cartilage: Importance of Anfibious and fish biological models to elucidate the function and evolution of these proteins. . 1º Meeting “O Mar e as Ciências da Saúde”. Universidade Nova de Lisboa (fa, Portugal).

2005. Júri de grau académico. Functional analysis of Bone related Gla Proteins from bony fish during skeletal development.

. Arguente principal. Gavaia, Paulo Jorge (Doutoramento). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2004/12/02 - 2004/12/04. Organização de evento. Organization commission of XIV Biochemistry National Congress, Vilamoura 2-4 December 2004, Portugal.

(2004). Sociedade Portuguesa de Bioquímica.

2004/12/02. Apresentação oral de trabalho. Effect of nacre extracts from the oyster Crassostrea gigas in the mineralization of bone-derived cells from Sparus aurata. XIV Biochemistry National Congress. SPB.

2004/12. Júri de grau académico. “Efeito de extractos de nacre da ostra Crassostrea gigas na mineralização de células de osso de Sparus aurata.". Arguente principal. Sofia Cavaco (Outro). Universidade do Algarve Faculdade de Ciências e Tecnologia.

2004/07. Júri de grau académico. “Estudo do metabolismo do cálcio e do efeito da PTHRP no transporte de cálcio, no intestino da dourada Sparus aurata”. Arguente principal. Joana Isabel da Silva Figueiredo (Outro). Universidade do Algarve.

2004 - 2004. Orientação. Effect of nacre extracts from the oyster Crassostrea Gigas in the mineralization of Sparus aurata bone cells. .Bioquímica (Licenciatura/Bacharelato). Orientador.

2003/12. Júri de grau académico. “Purificação e clonagem da proteína Gla da Matriz (MGP) em Prionace glauca (tubarão azul).". Arguente principal. Brian João Schaff (Outro). Universidade do Algarve.

2003/05/08. Apresentação oral de trabalho. Simultaneous detection of Osteocalcin and Matrix Gla Protein in developmental stages of Zebra fish (Danio rerio). 30th European Symposium on Calcified Tissues..

2003/05. Apresentação oral de trabalho. Acumulación y expresión de proteínas Gla de la matriz en lenguado, Solea senegalensis, y el pez cebra, Danio rerio. IX Congreso Nacional de Acuicultura, May, Cadiz, Spain (Gavaia PJ invited speaker).

2003 - 2003. Orientação. Purification and cloning of Prionace Glauca Matrix Gla protein.Biotecnologia (Licenciatura/Bacharelato). Orientador.

2000/12. Júri de grau académico. “Caracterização de uma cultura primária de células derivadas de osso de Dourada (Sparus aurata)”. Arguente principal. António José Ribeiro Pombinho (Outro). Universidade do Algarve Faculdade de Ciências e Tecnologia.

1998/07. Júri de grau académico. “Estudo da acumulação de cádmio na Ostra Portuguesa Crassostrea angulata (Lamarck, 1809)". Arguente principal. Miguel Jorge Nascimento Madureira (Outro). Universidade do Algarve.

Projetos

2023/01 - Presente. NutriK. Investigador responsável. Universidade do Algarve - Campus de Gambelas.

2021/01 - Presente. Algas na Praia/Seweeds on the beach online platform, Portugal 2020 (CRESC Algarve). Investigador responsável. Universidade do Algarve - Campus de Gambelas.

2021/01 - Presente. Algas na Praia. Co-Investigador Responsável (Co-IR). Universidade do Algarve - Campus de Gambelas.

2019/03 - Presente. SPN 2019 Application of Gla-rich Protein (GRP) in diagnostic and therapeutic of cardiovascular disease in Chronic Kidney Disease patients. . Investigador. Hospital de Faro; Centro de Ciências do Mar.

2019 - Presente. Characterization of bioengineered extracellular vesicles (EVs) loaded with Gla rich Protein: a proteomic approach (EU/H2020 EPIC-XS project #7), EPIC-XS, project number 823839, funded by the Horizon 2020 programme of the European Union. Investigador responsável. Centro de Ciências do Mar; VIB UGent Centrum voor Medische Biotechnologie.

2018 - Presente. GreenCoLAB- Laboratório Colaborativo de Tecnologias e Produtos Verdes de Oceano . Investigador. Centro de Ciências do Mar.

2017/04 - Presente. SPN 2016 Gla-rich protein (GRP) associated to circulating calciprotein particles (CPP) and extracellular vesicles (EVs) as a novel marker of vascular calcification stress in diabetic with chronic kidney disease (CKD). . Investigador. Hospital de Faro; Centro de Ciências do Mar.

2026/01 - 2027/12. Rugok4Health: Turning an Ecological Challenge into Health Innovation: Natural Vitamin K1 and Novel Bioactives from Rugulopteryx okamurae , FAM Foundation Grants 2025/26 Sustainable Development Goal 14 – Life Below Water. Investigador responsável. Universidade do Algarve Centro de Ciências do Mar.

2024/11/01 - 2027/10/30. XtremeGourmet 2.0 – Gastronomia e alimentação saudável com plantas halófitas, COMPETE2030-FEDER-01195200. Investigador. Universidade do Algarve - Campus de Gambelas.

2021/01/01 - 2025/12/31. Centre for Marine and Environmental Research, 6817 - DCRRNI ID. Universidade do Algarve Centro de Ciências do Mar; Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental.

2021/01 - 2025/12. Centro de Investigação Marinha e Ambiental.

2021/03 - 2025/03. ALGAE4IBD FROM NATURE TO BEDSIDE- ALGAE BASED BIO COMPOUND FOR PREVENTION AND TREATMENT OF INFLAMMATION, PAIN AND IBD, RIA. Investigador. Centro de Ciências do Mar.

2021/03/10 - 2023/12/31. Exploring a novel and sustainable sea-based diet supplement to promote longevity and quality of life in a pandemic era (NutriSafe), Programa Operacional CRESC Algarve 2020- FEDER – Fundo Europeu de Desenvolvimento Regional. Investigador responsável. Universidade do Algarve - Campus de Gambelas.

2021/12/01 - 2023/11/30. Exploring the therapeutic application of Gla-rich protein (GRP) in inflammation-related diseases using natural bioengineered nanovesicles, Concurso de Projetos de Investigação de Caráter Exploratório (PeX) em Todos os Domínios Científicos. Co-Investigador Responsável (Co-IR). Universidade do Algarve Centro de Ciências do Mar; Universidade Nova de Lisboa.

2021 - 2023. Exploring the therapeutic application of Gla-rich protein (GRP) in inflammation-related diseases using natural bioengineered nanovesicles (FlameGRP). Investigador. Centro de Ciências do Mar.

2021/11/21 - 2022/10/31. BIORREMEDIACIÓN DE DRENAJES ÁCIDOS DE ZONAS MINERAS DE LA EURORREGIÓN AAA UTILIZANDO MICROALGASUTILIZANDO MICROALGAS. Investigador. Centro de Ciências do Mar; Universidad de Huelva.

2020 - 2021. NUEVOS USOS DE SUBPRODUCTOS AGROALIMENTARIOS DE LA EURORREGIÓN ALENTEJO-ALGARVE-ANDALUCÍA UTILIZANDO MICROALGAS. Investigador. Universidad de Huelva; Centro de Ciências do Mar.

2017 - 2020. RED transfronteriza para el desarrollo de productos innovadores con microalgas, Programa de Cooperacão da União Europeia INTERREG VA POCTEP-055_ALGARED_PLUS_E Espanha Portugal. , INTERREG VA POCTEP. Investigador. Universidade do Algarve.

2019/01 - 2019/12. Centro de Ciências do Mar do Algarve.

2018/11/01 - 2019/05/31. Bioexplora: identificación de sustancias bioactivas de microalgas extremófilas obtenidas de zonas mineras de la Eurorregión Alentejo-Algarve-Andalucía. Investigador. Universidad de Huelva; Centro de Ciências do Mar.

2018/11/26 - 2018/12/14. Discovery of dermato-protective properties of marine 5-thiohistidines. . Orientador. Centro de Ciências do Mar.

2017/11/01 - 2017/11/15. Sustainable and high-efficient production of Tetraselmis suecica as innovative product with high biological value for cosmeceutical market. Orientador. Centro de Ciências do Mar.

2017/10/02 - 2017/10/17. Discovery of cosmeceutical and pharmaceutical properties of a promising marine natural product. Orientador. Centro de Ciências do Mar.

2014 - 2017. Expression and purification of Gla Rich protein in baculovirus for its use in functional and structural studies. . Investigador. Institut de Génétique et de Biologie Moléculaire et Cellulaire; Centro de Ciências do Mar.

2016 - 2016. Foresight Workshop, horizon scanning Exploitation and Legal Aspects on Marine Genetic and Chemical Resources. Investigador. Consiglio Nazionale delle Ricerche Area di Ricerca di Napoli 1.

2013/05/01 - 2015/12/31. New insigths into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP, 3599-PPCDT. Investigador. Hospital de Faro; Centro de Ciências do Mar; Universiteit Maastricht Cardiovascular Research Institute Maastricht.

2013/05 - 2015/12. New insigths into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP.

2013/05 - 2015/12. Novos conhecimentos sobre o mecanismo de calcificação vascular em doença renal crónica (DRC): o papel da GRP.

2012/02/01 - 2015/09/30. Insights into Gla-rich Protein (GRP) function and molecular mechanism of action in vascular calcification (BioGlaGRP), 3599-PPCDT. Investigador. Centro de Ciências do Mar; Hospital de Faro; Universiteit Maastricht Cardiovascular Research Institute Maastricht.

2012/03/01 - 2015/03/01. Application of 2DE proteomics to human articular cartilage and synovial fluid for identification of new osteoarthritis biomarkers (EU/H2020-PRIME-XS-72) . Investigador responsável. Centro de Ciências do Mar; VIB UGent Centrum voor Medische Biotechnologie.

2011/01/01 - 2014/06/30. A new approach for the identification of osteoarthritis terapeutic targets:The application of 2D-DIGE proteomics, Concurso para Projectos de I&D em todos os Domínios Científicos - 2009. Universidade do Algarve Centro de Ciências do Mar; Hospital de Faro.

2011/01 - 2014/06. A new approach for the identification of osteoarthritis terapeutic targets:The application of 2D-DIGE proteomics, 3599-PPCDT. Investigador responsável. Hospital de Faro; Centro de Ciências do Mar.

2011/01 - 2014/06. Nova abordagem para a identificação de alvos terapeuticos da osteoartrite: Aplicação da proteomica 2D-DIGE.

2011/01/01 - 2013/12/31. Projecto Estratégico - UI 4033 - 2011-2012, 6820 - DCRRNI ID. Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas; Universidade do Porto Faculdade de Desporto; Universidade de Trás-os-Montes e Alto Douro; Universidade do Algarve Centro de Ciências do Mar.

2010/01/01 - 2013/07/31. Studies for the establishement of GRP as a biomarker for vascular calcification, 3599-PPCDT. Investigador responsável. Hospital de Faro; Centro Hospitalar de Lisboa Central EPE; Universidade do Algarve.

2010/01/01 - 2013/07/31. Studies for the establishement of GRP as a biomarker for vascular calcification, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade do Algarve Centro de Ciências do Mar; Hospital de Faro; Centro Hospitalar Universitário de Lisboa Central EPE; Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve.

2010/01 - 2013/07. Studies for the establishement of GRP as a biomarker for vascular calcification.

2010/01 - 2013/07. Estudos conducentes ao establecimento da GRP como biomarcador da calcificação vascular.

2011/01 - 2012/12. Projecto Estratégico - LA 15 - 2011-2012.

2010 - 2012. Desenvolvimento de um alimento microencapsulado para larvas de peixes. Investigador. Centro de Ciências do Mar; Universidade do Algarve Centro de Investigação em Biomedicina.

2008/08/01 - 2011/11/30. HYDRAA - Improved dietary nitrogen formulations for marine fish larvae: effects on growth performance and skeletal formation, 3599-PPCDT. Investigador. Instituto Português do Mar e da Atmosfera; Centro de Ciências do Mar.

2007/08 - 2010/07. Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets, 3599-PPCDT. Investigador. Centro de Ciências do Mar.

2005/09/01 - 2008/06/30. MGP functional role regarding local regulation of extracellular matrix mineralization-Identification of the structural motifs responsible for its function, POCI. Investigador responsável. Centro de Ciências do Mar.

2005/09/01 - 2008/06/30. MGP functional role regarding local regulation of extracellular matrix mineralization-Identification of the structural motifs responsible for its function, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Universidade do Algarve Centro de Ciências do Mar.

2005/06 - 2008/06. Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis. Investigador. Centro de Ciências do Mar; Universidade do Algarve Centro de Investigação em Biomedicina.

2005/06 - 2008/06. Padrão de expressão espaço-temporal da Matrix Gla Protein (MGP) e sua regulação durante o desenvolvimento em X. laevis.

2005/11 - 2007/12. Dietary amino acids and skeletal development in white bream (Diplodus spp.).

2003/01 - 2006/01. Effect of extracellular calcium on MGP gene expression. Investigador. Centro de Ciências do Mar.

2003/01 - 2006/01. Mineralization processes in marine and fresh water teleosts: function of Gla proteins (Matrix Gla and osteocalcin). Investigador.

1998/01 - 2000. Characterization of Matrix Gla and Bone Gla proteins gene expression in different developmental stages of the seabream Sparus aurata. . Investigador. Centro de Ciências do Mar.

Produções

Vieira, Bárbara; Viegas, Carla; Freitas A; SIMES DC; Barreira, Luísa. Autor correspondente: Vieira, Bárbara. 2026. Valorization of Microalgae extracts in the cosmetic industry..

Viegas, Carla; Pichard, Simon; Carreira, Joana; Ova, Adélia; Troffer-Charlier, Nathalie; Maia, Teresa M.; Edelweiss, Evelina; et al. Autor correspondente: Viegas, Carla. 2026. "Bioengineered baculovirus-derived extracellular vesicles loaded with of ¿-carboxylated Gla-rich protein: Dual modulation of inflammation and vascular calcification". Biomaterials Advances, 184. https://doi.org/10.1016/j.bioadv.2026.214833

Marreiros C; Viegas, Carla; Silva, Ana; Nunes, Selene; Faísca, M; Schurgers, Leon; SIMES DC. Autor correspondente: SIMES DC. 2026. "Factors associated with Gla Rich Protein serum concentrations in healthy adults". Biochemia Medica.

Ana Paula Soares Dias; Francisco Ascenção Santos; Bruna Rijo; Dina Costa Simes; Leonel Pereira; Manuel Francisco Costa Pereira. 2025. "Seaweed-Derived Biochar for Effective Treatment of Dye-Contaminated Wastewater". Water. https://doi.org/10.3390/w17081215

María Robles; Carla S.B. Viegas; Rafael Torronteras; Inés Garbayo; José M. Vega; Dina C. Simes; Carlos Vílchez; et al. 2025. "An extremely acidic environment microalga from Tinto River as a novel source of anti-inflammatory activity". Plant Physiology and Biochemistry. https://doi.org/10.1016/j.plaphy.2025.109815

Ana Paula Soares Dias; Francisco Carreira das Neves Ascenção Carreira das Neves; Bruna Canuto Rijo; Dina Costa Simes; Leonel Pereira; Manuel Francisco Costa Pereira. 2025. Seaweed-Derived Biochar for Effective Treatment of Dye-Contaminated Wastewater. https://doi.org/10.20944/preprints202503.0704.v1

Carreira, Joana; Viegas, Carla; Arnaud, Poterszman; Pichard, Simon; Troffer-Charlier, Nathalie; Maia, Teresa M.; Macedo, Anjos L.; et al. Autor correspondente: Carreira, Joana. 2025. "Two systems, one goal: Optimizing EV production for GRP delivery". Trabalho apresentado em Third Meeting of the Portuguese Network on Extracellular Vesicles (PNEV), Faro, Portugal.

Viegas, Carla; Carreira, Joana; Arnaud, Poterszman; Pichard, Simon; Troffer-Charlier, Nathalie; Maia, Teresa M.; Macedo, Anjos L.; et al. Autor correspondente: Viegas, Carla. 2025. "Exploring the Baculovirus-Insect Cell system for extracellular vesicle production: The case of Gla-Rich Protein (GRP)". Trabalho apresentado em Third Meeting of the Portuguese Network on Extracellular Vesicles (PNEV), Faro, Portugal.

Silva, Mélanie; Avni D; Varela, João; Viegas, Carla; SIMES DC; Barreira, Luísa. 2025. Microalgae-Derived Bioactives: A Natural Approach to Combat Inflammation.

Vieira, Bárbara; Baia I; Paninho, Ana B.; Carreira, Joana; Ana V.M. Nunes; Grenha, Ana; Barreira, Luísa; et al. Autor correspondente: SIMES DC. 2025. Valorization of Macroalgae as a Sustainable Source of Vitamin K1 for Supplementation and Skin Health.

SIMES DC; Vieira, Bárbara; Barreira, Luísa; Viegas, Carla. 2025. Microalgae as a Source of Bioactive Compounds for Advanced Skincare Formulations..

SIMES DC; Jiménez, Javier; Viegas, Carla; Martins, Paula Ventura. Autor correspondente: SIMES DC. 2025. Monitoring invasive macroalgae with citizen science contribution: Algae on the Beach. Em OTTERS Conference: Waves of Change.

Marreiros C; Viegas, Carla; Malho Guedes, Anabela; Silva, Ana; Faísca M; Schurgers, Leon; SIMES DC. Autor correspondente: SIMES DC. 2025. Gla-Rich Protein as a Novel Biomarker for Cardiovascular Risk in Peritoneal Dialysis Patients. .

Sabotic, Jerica; Bayram, Engin; Ezra, David; Gaudêncio, Susana P.; Haznedaroglu, Berat Z.; Janež, Nika; Ktari, Leila; et al. 2024. "A guide to the use of bioassays in exploration of natural resources". Biotechnology Advances, 71. https://doi.org/10.1016/j.biotechadv.2024.108307

Marreiros, Catarina; Viegas, Carla; Guedes, Anabela Malho; Silva, Ana Paula; Águas, Ana Catarina; Faísca, Marília; Schurgers, Leon; Simes, Dina Costa. 2024. "Gla Rich Protein is associated with vascular calcification, inflammation and mineral markers in Peritoneal Dialysis Patients". J Clin Med, 13 (23). https://doi.org/10.3390/jcm13237429

Viegas, Carla; Carreira, Joana; Maia, Teresa; Impens, Francis; Macedo, Anjos; Matos, António; Simes, Dina. 2024. "Vascular calcification is mediated by different populations of extracellular vesicles (EVs) with specific molecular profiles and differential effects on vascular tissue inflammation". Atherosclerosis, 395. https://doi.org/10.1016/j.atherosclerosis.2024.117700

Carreira, Joana; Viegas, Carla; Poterszman, Arnaud; Pichard, Simon; Schnitzler, Charlotte; Maia, Teresa; Faria, Tiago; et al. 2024. "Gla-Rich Protein-loaded EVs for cardiovascular research: Production via baculovirus-insect and human cell systems". Trabalho apresentado em 2nd MOVE symposium, Belgrad, Sérvia.

Viegas, Carla; Carreira, Joana; Teresa M Maia; Francis Impens; Anjos L. Macedo; António Matos; Simes, Dina. Autor correspondente: Viegas, Carla. 2024. Vascular calcification is mediated by different populations of extracellular vesicles (EVs) with specific molecular profiles and differential effects on vascular tissue inflammation. Em European Atherosclerosis Society (EAS) 92th Congress,.

Viegas, Carla; Carreira, Joana; Maia, Teresa M.; Macedo, Anjos L.; Matos, António P.; Neves, José; Simes, Dina; et al. 2024. "Gla Rich Protein (GRP) Mediates Vascular Smooth Muscle Cell (VSMC) Osteogenic Differentiation, Extracellular Vesicle (EV) Calcification Propensity, and Immunomodulatory Properties". International Journal of Molecular Sciences. https://doi.org/10.3390/ijms252212406

Araújo, Nuna Cláudia Peixoto de. 2024. "Interplay between mineralization and inflammation in osteoarthritis: gla-rich protein and marine bioactive compounds as new therapeutic approaches". Doutoramento. http://hdl.handle.net/10400.1/25811

Pinto, Ezequiel; Viegas, Carla; Ventura Martins, Paula; Marreiros, Catarina; Nascimento, Tânia; Schurgers, Leon; Simes, Dina; Martins, Paula Ventura. 2024. "Mediterranean Diet favors Vitamin K intake: A descriptive study in a Mediterranean population". Nutrients, 16 (8). https://doi.org/10.3390/nu16081098

MARREIROS, CATARINA; Viegas, Carla; Malho Guedes, Anabela; Silva, Ana Paula de Andrade; Águas, Ana Catarina; Faísca, Marília; Schurgers, Leon; Simes, Dina. 2024. "Gla-Rich protein is associated with vascular calcification, inflammation, and mineral markers in peritoneal dialysis patients". https://doi.org/10.3390/jcm13237429

Barreira, Luísa; SIMES DC. 2024. IMPACT OF GASTROINTESTINAL DIGESTION ON BIOACTIVE PROPERTIES OF ALGAE EXTRACTS. Em Algaeurope 2024.

Vieira, Bárbara; Baía, Inês; Carreira, Joana; Viegas, Carla; Simes, Dina. 2024. "Vitamin K potential as an anti-aging supplement with antioxidant and anti-inflammatory activity". Trabalho apresentado em IX Clinical Biochemistry Workshop, Faro, Portugal.

Javier Jiménez Herrero; Dina Costa Simes; Rita Abecasis; Paulo Relvas; Erwan Garel; Paula Ventura Martins; Rui Santos; et al. 2023. "Monitoring invasive macroalgae in southern Portugal: drivers and citizen science contribution". Frontiers in Environmental Science. https://doi.org/10.3389/fenvs.2023.1324600

Marreiros C; Viegas, Carla; Malho Guedes, Anabela; Ana Paula Silva; Marilia Faisca; Schurgers, Leon; Simes, Dina. 2023. Establishment of Reference Intervals for Gla Rich Protein Serum levels and variations in a Peritoneal Dialysis Population. Em 6th International Scientific Congress of CiiEM - Immediate and future challenges to foster One Health.

Silva, Mélanie; Dorit Avni; Varela, João; Viegas, Carla; SIMES DC; Barreira, Luísa. 2023. A PATHWAY TOWARDS BETTER HEALTH: FIGHTING INFLAMMATION WITH NOVEL MICROALGAE-BASED NATURAL COMPOUNDS. Em ALGAEUROPE 2023.

Dorit Avni; Nathalie Shagug; Y Eilam; Antonio Marzochella; Daria Maria Monti; Antonino Pollio; Barreira, Luísa; et al. 2023. ALGAE AS A SUSTAINABLE FOOD BRIDGES THE REALMS OF HEALTH AND ENVIRONTMENTAL. Em ALGAEUROPE 2023.

Simes, Dina. 2023. "Gla Rich Protein is associated with vascular calcification, inflammation and mineral markers in Peritoneal Dialysis Patients". Trabalho apresentado em Congress EuroPD 2023, Bruges, Bélgica,27 de novembro, 2023, S37-S158.

Viegas, Carla; Carreira, Joana; Maia T; Durfour S; Francis, Impens; Anjos L. Macedo; Matos AP; Simes, Dina. 2023. Calcifying extracellular vesicles containing Gla-rich protein (GRP) modulate inflammatory responses in human macrophages.

Carla S. B. Viegas; Ova, Adélia; Carreira, Joana; Arnaud, Poterszman; Nathalie Troffer-Charlier; Tiago Faria; Sara Nascimento; Cristina Peixoto; Simes, Dina. 2023. "Exploring the therapeutic application of Gla-rich protein (GRP) in chronic inflammatory diseases using bioengineered nanovesicles". Trabalho apresentado em 2nd Meeting of the Portuguese Network on Extracellular Vesicles.

Pinto, Ezequiel; Viegas, Carla; Martins, Paula Ventura; Nascimento, Tânia; Schurgers, Leon; Simes, Dina; Ezequiel Pinto; et al. 2023. "New food frequency questionnaire to estimate vitamin K intake in a Mediterranean population". Nutrients. https://doi.org/10.3390/nu15133012

Pinto, Ezequiel; Viegas, Carla; Martins, Paula Ventura; Nascimento, Tânia; Schurgers, Leon; Simes, Dina. 2023. New Food-Frequency Questionnaire to Estimate Vitamin K intake in a Mediterranean Population. https://doi.org/10.20944/preprints202306.1831.v1

Catarina Marreiros; Carla Viegas; Dina Simes; Marreiros, Catarina; Viegas, Carla; Simes, Dina. 2022. "Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease". International Journal of Molecular Sciences. https://doi.org/10.3390/ijms232416114

Brancaccio, Mariarita; Milito, Alfonsina; Viegas, Carla Alexandra; Palumbo, Anna; Simes, Dina Costa; Castellano, Immacolata; S B Viegas, Carla; Simes, Dina. 2022. "First evidence of dermo-protective activity of marine sulfur-containing histidine compounds". Free Radical Biology and Medicine. https://doi.org/10.1016/J.FREERADBIOMED.2022.09.017

Mélanie Silva; Farah Kamberovic; Sisay Tesema Uota; Ismael-Mohammed Kovan; Carla S. B. Viegas; Dina C. Simes; Katkam N. Gangadhar; João Varela; Luísa Barreira. 2022. "Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals". Applied Sciences. https://doi.org/10.3390/app12125877

Carla S. B. Viegas; Carreira, Joana; Sara Dufour; Francis Impens; Anjos Macedo; António Matos; Simes, Dina. Autor correspondente: Carla S. B. Viegas. 2022. Deciphering the complexity of extracellular vesicles (EVs) mediated vascular calcification using a proteomic approach. Em 2nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies.

Marreiros C; Carla S. B. Viegas; Carreira, Joana; Simes, Dina. Autor correspondente: Marreiros C. "Papel da Gla Rich Protein (GRP) na saúde cardiovascular de doentes renais diabéticos - Respostas de um estudo clínico". Ualgoritmo, 2 (outubro, 2022): 4-8. https://viewer.joomag.com/ualgoritmo-1-1/M0933552001568756991

Viegas, Carla S. B.; Araújo, Nuna; Carreira, Joana; Pontes, Jorge F.; Macedo, Anjos L.; Vinhas, Maurícia; Moreira, Ana S.; et al. 2022. Nanoencapsulation of gla-rich protein (GRP) as a novel approach to target inflammation. Chronic inflammation is a major driver of chronic inflammatory diseases (CIDs), with a tremendous impact worldwide. Besides its function as a pathological calcification inhibitor, vitamin K-dependent protein Gla-rich protein (GRP) was shown to act as an anti-inflammatory agent independently of its gamma-carboxylation status. Although GRP’s therapeutic potential has been highlighted, its low solubi. https://doi.org/10.3390/ijms23094813

Cristafovici, Nicoleta; Pereira, Carla Margarida da Silva. 2022. "The role of vitamin K in osteoporosis". Mestrado. http://hdl.handle.net/10400.1/19474

Silva, Ana P.; Viegas, Carla S. B.; Guilherme, Patrícia; Tavares, Nelson; Dias, Carolina; Rato, Fátima; Santos, Nélio; et al. 2022. "Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD". Diagnostics, 12 (2). https://doi.org/10.3390/diagnostics12020496

Vieira, Bárbara Alexandra Ramires. 2022. "Evaluation of sargassum muticum as a source of vitamin K1 with anti-inflammatory and vascular protective properties". Mestrado. http://hdl.handle.net/10400.1/19092

Dina Simes. Autor correspondente: Dina Simes. 2021. Plataforma digital Algas na praia. https://form.jotform.com/212044035885352

SIMES DC. 2021. Guest Editor Special Issue "Vitamin K and Vitamin K-Dependent Proteins in Homeostasis and Pathology". A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".. https://www.mdpi.com/journal/ijms/special_issues/Vitamin_K-Dependent_Proteins#info

Dina Simes. Autor correspondente: Dina Simes. 2021. "Algas na praia: uma iniciativa de ciência cidadã para monitorizar acumulações de algas na costa portuguesa. Oral communication".

Simes, Dina; Carla S. B. Viegas. Autor correspondente: Simes, Dina. 2021. "Unveiling the complexity of extracellular vesicles (EVs) associated with vascular calcification: Heterogeneous populations with different characteristics and features. (Oral Presentation).".

Simes, Dina. Autor correspondente: Simes, Dina. 2021. Projeto piloto para criação de um questionário de frequência alimentar para determinar aporte de vitamina K numa população mediterrânica. . Em 1º Congresso da Rede de Instituições do Ensino Superior para a Salvaguarda da Dieta Mediterrânica.

Dina Simes. Autor correspondente: Dina Simes. 2021. "Preliminary Structural characterization of human Gla Rich Protein involved in the inhibition of mineral crystal formation in vascular calcification. (Oral poster)". Trabalho apresentado em XXI National Congress of Biochemistry, ÉVORA, Portugal.

SIMES DC. 2021. "Exploring the potential of the microalgae tetraselmis striata ctp4 as a novel source of anti-inflammatory compounds. ". Trabalho apresentado em XII European Conference on Marine Natural Products. Virtual Conference.

Araújo N; Viegas C; Perrolas I; Costa R; Magalhães J; Blanco F; Ramos A; et al. 2021. "Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay". Annals of medicine. http://europepmc.org/abstract/PMC/PMC7888949

Viegas C; Edelweiss E; Schneider J; Schaeffer-Reiss C; Poterszman A; Rafael M; Araújo N; et al. 2021. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of medicine. http://europepmc.org/abstract/PMC/PMC7888969

Araujo, Nuna; Viegas, Carla; Pontes, Jorge F.; Marreiros, Catarina; Raimundo, Pedro; Macedo, Anjos L.; de Matos, Antonio Alves; et al. 2021. "Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)". Annals of Medicine. https://doi.org/10.1080/07853890.2021.1896900

Ana P Silva; Carla SB Viegas; Filipa Mendes; Ana Macedo; Patrícia Guilherme; Nelson Tavares; Carolina Dias; et al. 2020. "Gla-Rich Protein (GRP) as an Early and Novel Marker of Vascular Calcification and Kidney Dysfunction in Diabetic Patients with CKD: A Pilot Cross-Sectional Study". Journal of Clinical Medicine. https://doi.org/10.3390/jcm9030635

Simes, Dina. 2020. "Vitamin K a nutraceutical with impact in health". https://doi.org/10.32545/encyclopedia202001.0002.v1

Dina C. Simes; Carla S. B. Viegas; Nuna Araújo; Catarina Marreiros. 2020. "Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases". Nutrients, 12 (1): 138-138. https://doi.org/10.3390/nu12010138

Devi, Meena; Awasthi, Shachi. 2020. "Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)". Trabalho apresentado em 4th congress of CiiEM on “Health, Well-Being and Ageing in the 21st Century”, Almada, Portugal. https://doi.org/10.1063/1.5122562

Pedrosa, Rui; P. Gaudêncio, Susana; Vasconcelos, Vitor. 2020. "Anti-inflammatory activity of microalgae-derived bioactives with potential dermoprotective applications". Marine Drugs, 18 (1). https://doi.org/10.3390/md18010040

Pedrosa, Rui; P. Gaudêncio, Susana; Vasconcelos, Vitor. 2020. "AMENTADIONE, A MERODITERPENOIDE FROM BROWN ALGAE WITH CAPACITY OF MODULATING OSTEOARTHRITIC RESPONSES, IN A CLOSE-TO-IN-VIVO OA MODEL". Marine Drugs, 18 (1). https://doi.org/10.3390/md18010040

Nuna Araújo; Carla S. B. Viegas; Eva Zubía; Joana Magalhães; Acácio Ramos; Maria M. Carvalho; Henrique Cruz; et al. 2020. "Amentadione from the Alga Cystoseira usneoides as a Novel Osteoarthritis Protective Agent in an Ex Vivo Co-Culture OA Model". Marine Drugs. https://doi.org/10.3390/md18120624

SIMES DC. "A relação entre a doença renal crónica e complicações cardiovasculares-será a proteína GRP a solução?". Ualgoritmo, 2020: 31-34. https://ualgoritmo.wixsite.com/website/c%C3%B3pia-u2-a2-5

Marreiros, Catarina; Ismael, Kovan; Viegas, Carla; Araujo, Nuna; Andrade, Miguel; Rosa, Bruno; Lima, Rui; et al. 2020. "Anti-Inflammatory Activity of Microalgae-Derived Bioactives with Potential Dermoprotective Apllications". Marine Drugs. https://publons.com/publon/32337057/

Araujo, Nuna; Viegas, Carla; Perrolas, Ines; Costa, Ruben; Marreiros, Catarina; Magalhaes, Joana; Blanco, Francisco; et al. 2020. "Amentadione, a Meroditerpenoide from Brown Algae with Capacity of Modulating Osteoarthritic Responses, in a Close-to-In-Vivo OA Model". Marine Drugs. https://publons.com/publon/32337056/

Viegas, Carla; Silva, Ana; Macedo, Ana; Mendes, Filipa; Guilherme, Patricia; Tavares, Nelson; Dias, Carolina; et al. 2020. "GLA-RICH PROTEIN (GRP) AS AN EARLY AND NOVEL MARKER ASSOCIATED WITH VASCULAR CALCIFICATION AND CKD-MINERAL AND BONE DISORDER (MBD) IN DIABETIC PATIENTS WITH CKD: A PILOT COHORT STUDY". Nephrology Dialysis Transplantation, 35 (Supplement). https://doi.org/10.1093/ndt/gfaa143.p0873

Dina C. Simes; Carla S. B. Viegas; Nuna Araújo; Catarina Marreiros. 2019. "Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies". International Journal of Molecular Sciences, 20 (17): 4150-4150. https://doi.org/10.3390/ijms20174150

Viegas, Carla; Araújo, Nuna; Marreiros, Catarina; Simes, Dina. 2019. "The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts". Aging, 11 (12): 4274-4299. https://doi.org/10.18632/aging.102046

Viegas, C.S.B.; Simes, D.C.. 2019. "A dual role for GRP in cardiovascular disease". Aging, 11 (5): 1323-1324. https://doi.org/10.18632/aging.101851

Simes, Dina; Marreiros, C.; Ismael, K.; Viegas, C.; Araújo, N.; Andrade, M.; Rosa, B.; et al. 2019. Anti-inflammatory Activity of Microalgae-derived Bioatives with Dermoprotective Application. Em Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products.

BrancaccioI, M.; Militol, A.; Viegas, C.; Simes, Dina; Castellano I. 2019. Marine 5-thiohistidines as protective molecules from skin damage. Em The 44th FEBS Congress.

Viegas, Carla; Edelweiss, Evelina; Schneider, Justine; Schaeffer-Reiss, Christine; Poterszman, Arnaud; Rafael, Marta; Araújo, Nuna; et al. 2019. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of Medicine, 51 (sup1): 38-38. https://doi.org/10.1080/07853890.2018.1561804

2019. "Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay". https://doi.org/10.1080/07853890.2018.1561895

Araújo, Nuna; Viegas, Carla; MARREIROS, CATARINA; Simes, Dina. 2019. "Amentadione, a meroditerpenoide from brown algae with capacity of modulating osteoarthritis responses, in a close-to-in-vivo OA model". Trabalho apresentado em Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products, Peniche, Leiria, Portugal.

Simes, Dina. 2018. "Gla-Rich Protein as a Novel Marker for Calcifications in Diabetic Patients with CKD ". https://doi.org/10.1093/ndt/gfy104.SP430

Simes, Dina. 2018. "Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases". https://doi.org/10.1080/07853890.2018.1427452

Viegas, C.S.B.; Santos, L.; Macedo, A.L.; Matos, A.A.; Silva, A.P.; Neves, P.L.; Staes, A.; et al. 2018. "Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: A role for GRP (Gla-Rich Protein)". Arteriosclerosis, Thrombosis, and Vascular Biology, 38 (3): 575-587. https://doi.org/10.1161/ATVBAHA.117.310578

Willems, B.A.; Furmanik, M.; Caron, M.M.J.; Chatrou, M.L.L.; Kusters, D.H.M.; Welting, T.J.M.; Stock, M.; et al. 2018. "Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling". Scientific Reports, 8 (1). https://doi.org/10.1038/s41598-018-23353-y

Viegas, Carla S. B.; Macedo, Anjos L.; Matos, Antonio A.; Silva, Ana P.; Neves, Pedro L.; Vermeer, Cees; Schurgers, Leon; Simes, Dina C.. 2018. "Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases". Annals of Medicine. https://publons.com/publon/18514686/

Viegas, Carla S.B.; Simes, Dina C.. 2018. "Inflammation and Calcification in the Vascular Tree; Insights Into Atherosclerosis". Em Immunity and Inflammation in Health and Disease, 189-201. Elsevier. https://doi.org/10.1016/b978-0-12-805417-8.00015-9

Silva, Ana Paula; Viegas, Carla; Simes, Dina; Mendes, Filipa; Tavares, Nelson; Rato, Fatima; Santos, Nelio; Neves, Pedro. 2018. "GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD". Nephrology Dialysis Transplantation, 33 (suppl_1): i493-i493. https://doi.org/10.1093/ndt/gfy104.sp430

Viegas CSB; Costa RM; Santos L; Videira PA; Silva Z; Araújo N; Macedo AL; et al. 2017. "Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.". PLOS ONE, 12 (5). https://doi.org/10.1371/journal.pone.0177829

Simes, Dina; Araújo, N.; Viegas, C.; Pontes, J.; Magalhães, J.; Blanco, F.; Macedo, A.; Grenha, A.. 2017. Nano-encapsulation of Gla-rich protein (GRP) and potential added value as a therapeutic agent for osteoarthritis. Em 21st International Symposium on Microencapsulation.

Marreiros, Catarina Isabel Lousada. 2017. "Clinical application of extracellular vesicles in vascular calcification". Mestrado. http://hdl.handle.net/10400.1/10566

Cavaco, Sofia Isabel Franco. 2017. "Studies towards unveiling the association of Gla-rich protein with osteoarthritis". Doutoramento. http://hdl.handle.net/10400.1/10803

Perrolas, Inês Madeira. 2017. "Bioactive marine compounds as novel therapeutics in osteoarthritis". Mestrado. http://hdl.handle.net/10400.1/10052

Viegas, Carla; Santos, Lucia; Macedo, Anjos; Morais, Rute; Silva, Ana; Neves, Pedro; Matos, Antonio; Vermeer, Cees; Simes, Dina. 2017. "CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN". Nephrology Dialysis Transplantation. https://publons.com/publon/28689989/

Morais R; Viegas CS; Simes DC; Matos AP; Macedo AL. 2017. "Application of TEM techniques for the study of vascular calcification: Monitoring extracellular vesicles and nanogold immunodetection of fetuin-A, GRP, and CD9.". https://doi.org/10.1080/01913123.2016.1272670

Viegas CS; Macedo AL; Morais R; Santos L; Matos AP; Silva AP; Neves P; Simes DC. 2017. "Dysregulated fetuin-mineral complexes are linked to vascular calcification in chronic kidney disease: The role of Gla-rich protein.". https://doi.org/10.1080/01913123.2016.1269490

Viegas, Carla; Santos, Lúcia; Macedo, Anjos; Morais, Rute; Silva, Ana; Neves, Pedro; Matos, António; Vermeer, Cees; Simes, Dina. 2017. "MO055CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN". Em Nephrology Dialysis Transplantation, iii67-iii68. https://doi.org/10.1093/ndt/gfx123.mo055

Viegas, C.S.B.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Vitorino, R.; Luís, I.M.; Costa, R.M.; et al. 2016. "Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system". Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (2): 399-408. https://doi.org/10.1161/ATVBAHA.114.304823

MacEdo, A.L.; Viegas, C.S.B.; Matos, A.P.A.; Simes, D.C.. 2016. "Extracellular vesicles and circulating fetuin-mineral complexes in vascular calcification; Studies by em techniques". Microscopy and Microanalysis, 22: 16-17. https://doi.org/10.1017/S1431927616000271

Simes, Dina. 2016. "New Perspectives for the Nutritional Value of Vitamin K in Human Health". J Nutr Disorders Ther . https://doi.org/10.4172/2161-0509.1000192

Simes, Dina. 2016. "Gla-rich Protein (GRP): A New Player in the Burden of Vascular Calcification". J Cardiovasc Dis Diagn . https://doi.org/10.4172/2329-9517.1000245

Cavaco, S.; Viegas, C.S.B.; Rafael, M.S.; Ramos, A.; Magalhães, J.; Blanco, F.J.; Vermeer, C.; Simes, D.C.. 2016. "Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis". Cellular and Molecular Life Sciences, 73 (5): 1051-1065. https://doi.org/10.1007/s00018-015-2033-9

Simes, Dina; Morais, R.; Viegas, C.; Matos, A.; Macedo, A.. 2016. Application of TEM Techniques for the Study of Vascular Calcification: Monitoring Extracellular Vesicles and NanoGold Immunodection of Fetuin-A, GRP and CD9. Em Ultrapath XVII, Society for Ultrastructural Pathology.

Simes, Dina; Araújo, N.; Perrolas, I.; Costa, R.; Viegas, C.; Ramos, A.; Zubia, E.. 2016. Exploring meroterpenoids from brown algae as novel therapeutic drugs for osteoarthriti. Em XV International Symposium on Marine Natural Products.

Richard, N.; Engrola, S.; Palma, P.S.; Simes, D.C.; Conceição, L.E.C.; Richard N; Engrola S; et al. 2015. "Assessment of protein digestive capacity and metabolic utilisation during ontogeny of Senegalese sole larvae: A tracer study using in vivo produced radiolabelled polypeptide fractions". Aquaculture, 441: 35-44. https://doi.org/10.1016/j.aquaculture.2015.02.003

Simes, Dina; Macedo, A.; Viegas, C.; Matos, A.. 2015. Extracellular Vesicles and Circulating Fetuin-Mineral Complexes in Vascular Calcification; Studies by EM Techniques. Em 4th Joint Congress of the Portuguese and Spanish Societies of Microscopy, "Microscopy at the Frontiers of Science 2015.

Simes, Dina; Morais, R.; Macedo, A.; Viegas, C.; Matos, A.. 2015. Electron Microscopy Contribution to the Study of Vascular Calcification Process: Monitoring Extracellular Vesicles Biogenesis and Mineralization. Em First International Congress of CiiEM. From Basic Sciences to Clinical Research.

Viegas, C.; Rafael, M.; Enriquez, J.; Teixeira, A.; Vitorino, R.; Costa, R.; Santos, L.; et al. 2015. "GLA-RICH PROTEIN (GRP) IS A NEW PLAYER IN MINERALIZATION-COMPETENCE OF EXTRACELLULAR VESICLES INVOLVED IN VASCULAR CALCIFICATION". Journal of Vascular Research. https://publons.com/publon/8974168/

Viegas, C.S.B.; Herfs, M.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Luís, I.M.; Van 'T Hoofd, C.M.R.; et al. 2014. "Gla-rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP-mineral interaction". BioMed Research International, 2014. https://doi.org/10.1155/2014/340216

Rafael, Marta S.; Cavaco, Sofia; Viegas, Carla S. B.; Santos, Sofia; Ramos, Acácio; Willems, Brecht A. G.; Herfs, Marjolein; et al. 2014. "Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ¿-carboxylation status". Molecular Nutrition & Food Research, 58 (8): 1636-1646. https://doi.org/10.1002/mnfr.201300941

Simes, Dina; Rafael, M.; Cavaco, S.; Viegas, C.; Santos, S.; Ramos, A.; Luis, I.; et al. 2014. Involvement of Gla rich protein (GRP) with pathological calcification during osteoarthritis. Insights into its ¿-carboxylation status. Em European Calcified Tissue Society (ECTS).

Simes, Dina; Santos, L.; Rafael, M.; Viegas, C.. 2014. Studies towards unveiling potential interaction partners of Gla-rich protein (GRP), a potential regulator of pathological calcification related diseases. Em XVIII Congress of the Portuguese Biochemical Society.

Simes, Dina; Costa, R.M.; Viegas, C.; Rafael, M.; Marques, G.; Silva, Z.; Videira, P.. 2014. Study of mineralization-related vitamin K-dependent proteins associated with leukocytes in mineralization and inflammatory processes. Em XVIII Congress of the Portuguese Biochemical Society.

Santos, Lúcia Alexandra Rosa dos. 2014. "Interaction studies of Gla-rich protein with bone morphogenetic proteins". Mestrado. http://hdl.handle.net/10400.1/7922

Rafael, Marta; Cavaco, Sofia; Viegas, Carla; Santos, Sofia; Ramos, Acacio; Luis, Ines; Costa, Ruben; et al. 2014. "Involvement of Gla rich protein with pathological calcification during osteoarthritis. Insights into its ¿-carboxylation status". Em Bone Abstracts. https://doi.org/10.1530/boneabs.3.pp373

Carla S. B. Viegas; Dina C. Simes; Matthew K. Williamson; Sofia Cavaco; Vincent Laizé; Paul A. Price; M. Leonor Cancela; et al. 2013. "Sturgeon Osteocalcin Shares Structural Features with Matrix Gla Protein". Journal of Biological Chemistry, 288 (39): 27801-27811. https://doi.org/10.1074/JBC.M113.450213

Cavaco, Sofia; Williamson, Matthew K.; Rosa, Joana; Roberto, Vânia; Cordeiro, Odete; Price, Paul A.; Leonor Cancela, M.; Laizé, Vincent; Simes, Dina C.. 2013. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry, 40 (3): 731-738. https://doi.org/10.1007/s10695-013-9880-9

Willems, B. A. G.; Chatrou, M. L. L.; Kusters, H. M.; Theuwissen, E.; Simes, D.; Vermeer, C.; Reutelingsperger, C. P. M.; Schurgers, L. J.. 2013. "GRP/Ucma: a novel member of the class of vitamin K-dependent proteins is involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells". Journal of Thrombosis and Haemostasis. https://publons.com/publon/18514688/

Oliveira, D.V.; Silva, T.S.; Cordeiro, O.D.; Cavaco, S.I.; Simes, D.C.; Oliveira, Daniel; Silva, Tome S.; et al. 2012. "Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach". The Scientific World Journal, 2012. https://doi.org/10.1100/2012/765909

Cavaco, S.I.; Viegas, C.B.; Marta, R.; Acácio, R.; Silva, J.; Morera, J.L.; Teixeira, A.; et al. 2012. "Gla rich protein (grp) is associated to osteoarthritis being highly accumulated in the joint tissues and synovial fluid". Osteoarthritis and Cartilage, 20: S90-S91. https://doi.org/10.1016/j.joca.2012.02.090

Simes, Dina; Rafael, M.; Viegas, C.; Miralles-Ferrer, N.; Vermeer, C.. 2012. Production of functional recombinant Gla-rich protein (GRP) for clinical diagnosis. Em Practical workshop on Production, purification and characterization of macromolecular complexes IGBMC.

Simes, Dina; Viegas, C.; Morera, J.L.; Teixeira, A.; Joao, A.; Ferreira, A.; Neves, P.; et al. 2011. GRP is a new VKD protein associated with ectopic calcifications and potential application in clinical diagnostics. Em FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of VitaminK & Vitamin K Dependent Proteins.

Simes, Dina; Viegas, C.; Cavaco, S.; Ramos, A.; Silva, J.; Morera, J. L.; Teixeira, A.; et al. 2011. Insights into the relation between Gla rich protein (GRP) and Osteoarthritis. Em FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K Dependent Proteins.

Simes, Dina; Herfs, M.; Smit, E.; Viegas, C.; Vermeer, C.. 2011. Gla-rich protein: a new vitamin K-dependent protein associated with inflammation. Em FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K Dependent Proteins.

Maria, Vera Lúcia Teixeira de Jesus. 2011. "Produção e purificação da proteína rica em gla (grp) humana recombinante". Mestrado. http://hdl.handle.net/10400.1/3790

Cavaco, S. I.; Viegas, C.; Cordeiro, O.; Vareilles, M.; Silva, T.; Palma, P.; Simes, D.. 2011. "Identification and characterization of GRP in articular cartilage and synovial fluid using a proteomic-based approach". Bone. https://doi.org/10.1016/J.BONE.2011.03.652

Simes, Dina; Viegas, C.; Cavaco, S.; Neves, P.L.; Joao, A.; Williamson, M.K.; Price, P.A.; Cancela, L.. 2010. GRP is a New Vitamin K Dependent Protein and a Possible Ectopic Calcification Biomarker with Diagnostic Implications. Em BIT’s 3rd Annual Protein and Peptide Conference.

Simes, Dina; Oliveira, D.; Cavaco, I.; Silva, T.S.; Cordeiro, D.C.; Rodrigues, P.M.. 2010. Proteomic analysis of nacre soluble matrix proteins from the oyster Crassostrea Gigas. Em 4th EUPA meeting and 6th ProCura meeting, .

Simes, Dina; Cavaco, S.; Viegas, C.. 2010. 2-DE Proteomics of human articular cartilage for the identification of osteoarthritis biomarkers - procedures optimization. Em 4th EUPA meeting and 6th ProCura meeting.

Viegas, C. S. B.; Conceição, N.; Fazenda, C.; Simes, D. C.; Cancela, M. L.. 2010. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology, 26 (2): 214-218. https://doi.org/10.1111/j.1439-0426.2010.01408.x

Leonor Cancela; Simes, Dina; S B Viegas, Carla; Viegas, CSB; Cancela, M.L.. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof". Expirada.

Simes, Dina; Fazenda, C.; Conceiçao, N.; Cancela, L.. 2009. Development of molecular and cellular tools to study the function of skeletal Gla-containg proteins in sturgeon. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.

Viegas, C.S.B.; Cavaco, S.; Neves, P.L.; Ferreira, A.; João, A.; Williamson, M.K.; Price, P.A.; et al. 2009. "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications". American Journal of Pathology, 175 (6): 2288-2298. https://doi.org/10.2353/ajpath.2009.090474

Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)".

Roberto, Vânia P.; Cavaco, Sofia; Viegas, Carla S.B.; Simes, Dina C.; Ortiz-Delgado, Juan-Bosco; Sarasquete, M. Carmen; Gavaia, Paulo J.; Cancela, M. Leonor. 2009. "Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation". Aquaculture, 294 (3-4): 202-211. https://doi.org/10.1016/j.aquaculture.2009.06.020

Cavaco, Sofia Isabel Franco. 2009. "Purificação e caracterização de proteínas Gla nos modelos peixe e mamífero". Mestrado. http://hdl.handle.net/10400.1/541

Viegas, C. S. B.; Simes, D. C.; Williamson, M. K.; Laize, V.; Price, P.; Cancela, L.. 2008. "Identification of an MGP/OC hybrid gene in the adriatic sturgeon (acipencer naccarit), an ancient bony fish with a cartilaginous endoskeleton". Em Calcified Tissue International 82, S12-S22.

Simes, Dina; Laize, V.; Viegas, C.; Cancela, L.. 2008. Evolutionary relationship of bone-associated Gla proteins. Em 2nd meeting of the European Society for Evolutionary Development Biology.

Viegas, C.S.B.; Simes, D.C.; Laizé, V.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Viegas, C. S. B.; et al. 2008. "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates". Journal of Biological Chemistry, 283 (52): 36655-36664. https://doi.org/10.1074/jbc.M802761200

Dina C. Simes; Carla B. Viegas; Matthew K. Williamson; Paul A. Price; Leonor Cancela. 2008. "Purification of matrix Gla protein and osteocalcin from the adriatic sturgeon (Acipencer naccarii), an Ancient bony fish with a cartilaginous endoskeleton". Bone, 42: S65-S65. https://doi.org/10.1016/j.bone.2007.12.116

Viegas, Carla; Simes, Dina; Williamson, M.K.; Laizé, V.; Price, PA; Cancela, ML. 2008. "Identification of an hybrid gene in the Adriatic sturgeon (Acipenser naccarii), an ancient bony fish with a cartilaginous endoskeleton". Em Calcified Tissue International, S121-S122.

Viegas, C.S.B.; Simes, Dina; Williamson, M.K.; Laizé, Vincent; Price, Paul A.; Cancela, M. Leonor. 2008. "Identification of an MGP/OC hybrid gene in the Adriatic sturgeon (Acipencer naccarii), an ancient bony fish with a cartilaginous endoskeleton". Trabalho apresentado em 35th ECTS Meeting, May 24-28, Barcelona, Spain. https://doi.org/10.1007/s00223-008-9118-5

Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; et al. 2006. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns, 6 (6): 637-652. https://doi.org/10.1016/j.modgep.2005.11.010

Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.; J. B. Ortiz-Delgado; et al. 2006. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology, 126 (1): 89-101. https://doi.org/10.1007/s00418-005-0125-6

Simes, Dina; Viegas, C.; Cancela, L.. 2006. Molecular cloning and regulation of the genes encoding Matrix and Bone Gla proteins from Sturgeon. Studies towards understanding the evolution of their molecular mechanism of action. Em Seminários Mar e Ambiente.

Frazão, Carlos; Simes, Dina C.; Coelho, Ricardo; Alves, Dora; Williamson, Matthew K.; Price, Paul A.; Cancela, M. Leonor; Carrondo, Maria A.. 2005. "Structural Evidence of a Fourth Gla Residue in Fish Osteocalcin: Biological Implications". Biochemistry, 44 (4): 1234-1242. https://doi.org/10.1021/bi048336z

Dina Simes. 2005. "Constitutive expression of Sparus aurata osteocalcin in a chondrocytic-like (VSA13) and osteoblastic-like cell line (VSA16): Effect on mineralization rate and levels of calcification-related gene expression". Bone. https://publons.com/publon/13755101/

Ortiz-Delgado, J. B.; Simes, D. C.; Gavaia, P.; Sarasquete, C.; Cancela, M. L.. 2005. "Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology, 124 (2): 123-130. https://doi.org/10.1007/s00418-005-0015-y

Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. 2005. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution".

Paulo Gavaia. 2005. "Osteocalcin and matrix Gla protein in developing teleost teeth. Identification of sites of expression and protein accumulation". Bone. https://publons.com/publon/565424/

Pessoa, J.C.; Calhorda, M.J.; Cavaco, I.; Costa, P.J.; Correia, I.; Costa, D.; Vilas-Boas, L.F.; et al. 2004. "N-Salicylideneamino acidato complexes of oxovanadium(IV). the cysteine and penicillamine complexes". Dalton Transactions, (18): 2855-2866. https://doi.org/10.1039/b404305g

Simes, D. C.; Williamson, M. K.; Schaff, B. J.; Gavaia, P. J.; Ingleton, P. M.; Price, P. A.; Cancela, M. L.. 2004. "Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Studies in Lower Vertebrates". Calcified Tissue International, 74 (2): 170-180. https://doi.org/10.1007/s00223-003-0079-4

Simes, DC; Williamson, MK; Ortiz-Delgado, JB; Viegas, Csb; Price, PA; Cancela, ML. 2003. "Purification of Matrix Gla Protein From a Marine Teleost Fish, Argyrosomus regius: Calcified Cartilage and Not Bone as the Primary Site of MGP Accumulation in Fish". Journal of Bone and Mineral Research, 18 (2): 244-259. https://doi.org/10.1359/jbmr.2003.18.2.244

Simes, Dina; Gavaia, P.; Ortiz-Delgado, J.B.; Cancela, M.L.; Sarasquete, C.. 2003. Acumulación y expresión de proteínas gla de la matriz en lenguado, Solea senegalensis y el pez cebra Danio rerio. Em IX Congreso nacional de acuicultura.

Gavaia, Paulo J.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. 2003. "Simultaneous detection of osteocalcin and matrix gla protein in developmental stages of zebra fish (Danio rerio)". https://doi.org/10.1007/s00223-003-5002-5

Moura, José J. G.; Simes, Dina C.; Bebianno, Maria João; Dina C. Simes; Maria João Bebianno; José J.G. Moura; Simes, D.C.; Bebianno, M.J.; Moura, J.J.G.. 2003. "Isolation and characterisation of metallothionein from the clam Ruditapes decussatus". Aquatic Toxicology, 63 (3): 307-318. https://doi.org/10.1016/s0166-445x(02)00185-6

Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. 2002. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene, 289 (1-2): 97-107. https://doi.org/10.1016/S0378-1119(02)00480-8

Simes, Dina; Coelho, R.; Alves, D.; Frazão, C.; Cancela, M.L.; Carrondo, M.A.. 2002. Crystallization of Osteocalcin from a Marine Fish, Argyrosomus regius. Em IX International Conference on the crystallization of Biological macromolecules (ICCBM).

Simes, Dina Cristina F. R. Costa. 2002. "Purification, biochemical characterization and localization at single cell resolution of Matrix Gla Protein (MGP) and Bone Gla Protein (BGP) in the teleost fish Argyrosomus regius". Doutoramento. http://hdl.handle.net/10400.1/8458

Pinto, J. P.; Gavaia, Paulo J.; Simes, Dina; Kelsh, R. N.; Cancela, Leonor; Simes, Dina; Pinto, J.; et al. 2001. Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization. Em FEBS Lisbon 2001, PABMB.

Simes, Dina; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Pinto, J. P.; Cancela, Leonor; Paulo Gavaia. 2001. "Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates.". Bone. http://hdl.handle.net/10400.1/4426

SIMES DC. 2001. Obtention of fish MGP specific antibodies and characterization of specific MGP accumulation in Argyrosomus regius bone and calcified cartilage. Em FEBS Lisbon 2001, PABMB.

Pessoa, J.C.; Cavaco, I.; Correia, I.; Costa, D.; Henriques, R.T.; Gillard, R.D.. 2000. "Preparation and characterisation of new oxovanadium(IV) Schiff base complexes derived from salicylaldehyde and simple dipeptides". Inorganica Chimica Acta, 305 (1): 7-13. https://doi.org/10.1016/S0020-1693(00)00102-X

Dina Simes. 2000. "Expression of matrix Gla protein (MGP) in fish and amphibian: A model system to study the evolution of MGP function.". Journal of Bone and Mineral Research. https://publons.com/publon/13755133/

Simes, Dina; Pinto, J.P.; Rodrigues, P.; Macedo, L.; Goodfelow, B.; Williamson, M.K.; Price, P.A.; Cancela, M.L.. 2000. Identification of invariant amino acid residues in BGP from fish to mammals suggests a conserved function throughout vertebrate evolution. Em 20th Conference of European Comparative Endocrinologists.

Simes, Dina; Cancela, M.L.; Rodrigues, P.; Conceição, N.; Reia, J.P.; Williamson, M.K.; Price, P.A.. 2000. Expression of MGP in fish and amphibians: A model system to study the evolution of MGP function. Em 20nd Annual Meeting of the American Society for Bone and Mineral Research.

Simes, Dina; Williamson, M.K.; Price, P.A.; Cancela, M.L.. 2000. Identification of matrix Gla protein in a teleost fish: calcified cartilage and not bone as the primary site of expression in fish. Em XII Biochemistry National Congress.

Bebianno, Maria João; Serafim, MA; Simes, Dina; Bebianno, M.J.; Serafim, M.A.; Simes, D.; M. J. Bebianno; et al. 2000. "Metallothioneins in the clam Ruditapes decussatus: an overview". Analusis, 28 (5): 386-390. https://doi.org/10.1051/analusis:2000280386

Simes, Dina; Costa, C.; Moura, I.; Moura, J.J.G.. 1998. The equilibrium monomer dimer of Cytochrome c550 from Paracoccus denitrificans NMR spectroscopic studies. Em Gordon Research Conference “Magnetic Nuclear Resonance in Biology and Medicin.

Simes, Dina; Bebiano, M.J.; Moura, J.J.G.. 1997. Purification and parcial caracterization of metallothioneins from the clam Ruditapes decussatus. Em 3ª Conferência de Química Inorgânica “Síntese, Reactividade e Estrutura em Química Inorgânica”, .

Cavaco, I.; Pessoa, J.C.; Costa, D.; Duarte, M.T.; Gillard, R.D.; Matias, P.. 1994. "N-salicylideneamino acidate complexes of oxovanadium(IV). Part 1. Crystal and molecular structures and spectroscopic properties". Journal of the Chemical Society, Dalton Transactions, (2): 149-157. https://doi.org/10.1039/DT9940000149

Simes, Dina; J. Costa; Cavaco, I.; Villas Boas, L.. 1992. Reactions of Copper(II) and oxovanadium (IV) glycine schiff base complexes with acetone. Em Second Italian- Portuguese- Spanish Meeting in Inorganic Chemistry.

Roseiro JC; Costa DC; Collaco MTA; Roseirol, J.C.; Costa, D.C.; Collaço, M.T.A.. 1992. "Batch and fed-batch cultivation of Xanthomonas campestris in carob extracts.". Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire, 25 (3): 289-293. http://europepmc.org/abstract/AGR/IND93002142

Dina Cristina Fernandes Rodrigues da Costa Simes

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