Path4Med is a multi-actor and participatory Innovation Action project composed of scientific experts in public institutions, solutions and services providers in private companies, farmers’ associations and land managers, and various stakeholders (technology providers, recipients, consumers, facilitators, water user associations, citizens etc.) and will achieve its objectives through co-learning and co-development to maximise the size, the importance, and the endurance of its impact long after the project completion. A set of 7 integrated, multisite, multiscale, and multidisciplinary Demonstration Groups (DGs) involving 11 Demonstration Sites (DS) (Figure 3) that will be co-designed, implemented, and operated in critical regions in the Mediterranean and throughout Europe using the Living Labs approach and that will act as innovation incubators, ensuring the relevance and the pertinence of the project outcomes to the specific needs of all involved actors and will maximize the impact and the exploitation potential of the obtained results. Well-designed clustering activities also play a key role in forming synergies with the relative projects funded under the soil mission, the ocean and water mission, and biobased economy calls with emphasis on replicating Path4Med solutions to the Living Labs (LLs and demo-sites developed in these projects or to integrate our demo-sites to existing LLs and to utilize solutions developed in these projects in our integrated approach. Clustering activities and an open call for the financial support to third parties will allow the engagement of a big number (at least five) of associated regions replicating and upscaling the solutions developed within Path4Med all around the Mediterranean and in other European seas facing similar problems.